Efficacy analysis of Traditional Chinese Medicine Syndrome Differentiation on Pneumoconiosis

Objective: To study the clinical effect of TCM syndrome differentiation and treatment on pneumoconiosis. Methods: Randomly selected 160 cases of pneumoconiosis patients admitted to our hospital, stratified randomly divided into the experimental group and the control group;The control group was given conventional oxygen and nursing therapy,the experimental group on the basis of the control group was given TCM syndrome differentiation. Two groups of patients had to finished the SGRQ before and after treatment, And use the method of immunofluorescence to check out the content of procollagen type III(PCIII), collagen type IV(IV-C), hyaluronic acid(HA) and laminin(LN) in serum in the two groups of patients before and after treatment. Two groups of clinical effect will been judged in one month. Results: The two groups in age, the cumulative dust length, the content of four parameters of fibrosis in serum, SGRQ each score and total score had no difference(P>0.05); In the two groups after treatment, there is difference on the content of PCIII in serum, respiratory symptoms, sickness influence and total score, with statistical significance(P<0.05). The experimental treatment efficiency is higher than the control group treatment efficiency. Conclusion: Traditional Chinese Medicine syndrome differentiation and treatment on pneumoconiosis, can delay the development of patients ' condition, have the effect on easing patients' clinical symptoms, and have no obvious adverse reactions.


Introduction
Pneumoconiosis is due to the long-term inhalation of productive dust in professional activities, and retention in the lung, mainly diffuse fibrosis of lung tissue caused by systemic diseases [1] . The main clinical symptoms of respiratory are cough, sputum, chest pain and dyspnea; In addition there are breathing, hemoptysis and some systemic symptom.
Pneumoconiosis once occurred, a progressive development, not only endanger the health of the workers exposed with dust and reduce the labor ability and quality of life, and ultimately cause huge economic loss to the country [2][3] . At present, It is lack of effective treatment methods in the treatment of pneumoconiosis, application of western medicine treatment of pneumoconiosis is given priority to with glucocorticoid and immunosuppressants at home and abroad , due to its side effect is remarkable, and its treatment effect is not ideal, its application is limited for certain in clinical.
Pneumoconiosis in TCM belongs to Lung withered.
Dust inhaled into lung deposit in the lung with impairment of lung, and it go against breath. So develop some symptoms such as cough, oppression in chest, short breath and so on [4][5][6] . Lung disease do not improve for a long time that will hurt the spleen and stomach. The deficiency of lung will result in dysfunction of spleen in transportation, and develop some symptoms of spleen-qi deficiency such as shortness of breath and slow statement,floating face and swollen feet and so on. The deficiency of lung-qi cause further the symptoms of kidney deficiency. It follows that the development of pneumoconiosis is the chronic evolution process that deficiency develops in lung, spleen and kidney, and then cause deficiency in five organs; Therefore, dryness-heat, phlegm and blood stasis and weakened body resistance are three key for the pathogenesis of pneumoconiosis [7][8] . 95 different syndrome types with the corresponding medicinal broth.

The observed indexes
The change of signs and symptoms that include cough, sputum, chest tightness, chest pain, dyspnea, lung rale and so on before and after treatment; SGRQ each score and total score, SGRQ table is applied to assess the quality of life(QOL) in patients with chronic obstructive pulmonary disease(COPD) in our country, the results show that the table has a good reliability and validity [10] ; The content of four parameters of fibrosis in serum, before and after treatment; The curative effects judgment of two groups, the judging principle refer to the guidelines of diagnosis and treatment on idiopathic pulmonary fibrosis(mesenchymal) [11] .

Statistical analysis
Using SPSS18.0 software for data entry and statistical analysis. All the measurement data were expressed as the Means±SD.Analyze count data by chi-square test; Variance test or T test is used to analyze the measurement data conforms to normal distribution, parameter test is used to analyze the non-normal distribution. Probability values lower than 0.05 were considered statistically significant.

Population distribution analysis
Two observation group had no difference in age, the length of exposure to dust, gender distribution and pneumoconiosis stage(P>0.05).All data are shown in

Discussions
Pneumoconiosis is the main occupational disease in our country at present; Not only the quantity of patients is large, and the damage of disease is great, and it lead to a serious loss of labor ability and disability; But also it is the main occupational diseases for national and corporate compensation. Pneumoconiosis is a chronic progressive occupational disease, its pathological changes is diffuse fibrosis of lung tissue, and fibrosis is repairing mechanism after lung injury [12] ; Theoretically, To achieve these purposes, current treatment is mainly focused on the comprehensive treatment.
At present, the treatment of pneumoconiosis is lack of effective treatment; Western medicine commonly used corticosteroids and immunosuppressant therapy, but the treatment effect is not satisfied, and the side effects is great, the specificity is poor; There is little probability of long-term application. In recent years, many scholars [13][14][15]  The clinical feature of the syndrome of phlegm and blood stasis is that muscular articulation with stabbing pain, skin is dark purple and swelling, with oppression in chest, tongue is dark purple or with ecchymoses, coated tongue is white and greasy, pulse string. Its prescription is xuefu zhuyu decoction with erchen decoction. The function of the xuefu zhuyu decoction is that promoting blood circulation to remove blood stasis and promoting qi circulation and relieving pain.