Cationic Quaternized Chitosan Nanoparticles for C-phycocyanin Delivery to Hela Cells

Cationic Quaternized Chitosan Nanoparticles for C-phycocyanin Delivery to Hela Cells

Author(s)

Peng Yang, Bing Li, Cong-Yi Lv, Qi-Feng Yin, Yu-Juan Wang

Download Full PDF DOI: 10.18483/ijSci.834 Downloads: 111 Views: 261 Pages: 17-23

Volume 4 - September 2015 (09)

Abstract

In this study we synthesize C-PC/QAC nanoparticles using cationic quaternary ammonium chitosan (QAC) as substrate material loaded C-phycocyanin (C-PC) by ionic-gelation method. The prepared NPs was about 120nm size with spherical morphology, the entrapment efficient was 62%, and the drug-loading amount was 20%. The NPs exhibited a pH sensitive realease of C-PC in vitro. The drug-NPs were proved to be hemocompatible and safe. In conclusion, QAC increased bioavailability and anticancer property of C-PC.

Keywords

Cancer Therapy, Drug Delivery, C-phycocyanin·Quaternary, Ammonium Chitosan, Nanoparticles

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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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