Author(s): Yuan Wang, Jianhui Tian, Yongchen Sun, Xiaxia Wang
Objective: Research had shown that hypertension was the main risk factor for coronary heart disease (CHD). Hypertension with microalbuminuria (MAU) is the important mark of target organ damage and endothelial function impaired, and also the independent factor for CHD. This paper aimed to explore the mechanism that patients with hypertension combined MAU increased the risk of CHD by investigating the relationship between MAU and IL-6, ET-1, NO in patients with essential hypertension (EH).
Methods: To select 132 patients with essential hypertension who were hospitalized in the affiliated hospital of Qingdao university from October 2014 to July 2015. According to the MAU levels, there were 2 experimental groups in this experiment: MAU positive group (MAU>30 mg/l) and MAU negative group (MAU<30 mg/l). And 50 healthy persons in physical examination center of the same hospital were selected as a normal control group. All patients were performed blood routine, urinary routine, stool routine and biochemical analysis. IL-6 level and ET-1 level were measured by enzyme-linked immunosorbent assay. NO level was determined by nitrate reductase method. Statistical analysis was performed by SPSS version 19.0.
Results: The serum IL-6 (103.45±4.89pg/ml), ET-1 (209.62±5.00pg/ml) and systolic blood pressure (174.59±25.75mmHg) levels in MAU positive group were obviously higher than that in the MAU negative group. The difference was statistically significant (P< 0.05). The serum NO level (19.76±2.48umol/l) in MAU positive group was significantly lower than that in the MAU negative group. The difference was statistically significant (P<0.05). The multi-factor regression analysis showed that the IL-6 (B=0.206, p=0.021), ET-1 (B=0.594, p<0.01), were positively correlated to MAU, while NO (B=-0.380, p=0.012) was negatively correlated to MAU.
(1) The levels of IL-6 and ET-1 in hypertensive patients with MAU increased significantly, and the NO level decreased.
(2) IL-6，ET-1 were positively correlated to MAU, while NO was negatively correlated to MAU.
(3) Hypertension with MAU has important clinical significance. It needs more attention and effective management.
Essential hypertension, Microalbuminuria, Interleukin-6, Endothelin-1, Nitric Oxide, Coronary heart disease
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