Pregnant women with medical disorders may associated with multiple changes in platelet indices parameters. It may be arising from hemodilution or increased platelet consumption during uteroplacental circulation. Platelet indices (PI) are a group of derived platelet parameters extracted as a part of the automatic complete hemogram. This study aimed to investigate the potential role of Platelets as a diagnostic or prognostic marker across the disease associated with Sudanese pregnancies. A cross-sectional study was conducted in March 2015 at Port Sudan Teaching Hospital, Port Sudan, Sudan. 40 Sudanese pregnant women with different medical complications were enrolled and 10 well pregnant women were included in this study. In both, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet large cell ratio (P-LCR) and platelet cell concentration (P-LCC) were done. The pregnant women with medical association in compared with well pregnant women were found to be significant in the MPV, PDW, P-LCR, and P-LCC (P < 0.022, 0.036, 0.021 and 0.040 respectively). In contrast, PLT and PCT were found to be insignificant (P< 0.871 and 0.666). However, platelet indices were higher in patients than in controls except for the PLT and PCT level no changes were displayed. Accordingly, the convincing laboratory evidences in this study show that the usefulness of platelet indices as marker for medical disorders associated with pregnancy. The MPV and PDW are potential markers in the predicting disease severity.
Platelet indices, MPV, PDW, Pregnant women, Port Sudan
- Babu E and Basu D (2004). Platelet large cell ratio in the differential diagnosis of abnormal platelet counts. Indian J Pathol Microbiol 47(2): 202-205.
- Budak YU, Polat M, Huysal K (2016). The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Boichemia Medica, 26 (2): 178 – 93.
- Ceyhan T, Beyan C, Baser I, et al. (2006) The Effect of Preeclampsia on Complete Blood Count, Platelet Count and Mean Platelet Volume. Annals of Hematology, 85, 320-322.
- Chandrashekar V (2013). Plateletcrit as a screening tool for detection of platelet quantitative disorders. J Hematol. 2: 22 – 6.
- Dadhich S, Agrawal S, Soni M et al (2012) Predictive Value of Platelet Indices in Development of Preeclampsia. Journal of SAFOG with DVD, 4, 17-21.
- Dundar O, Yoruk P, Tutuncu L, et al. (2008) Longitudinal Study of Platelet Size Changes in Gestation and Predictive Power of Elevated MPV in Development of Preeclampsia. Prenatal Diagnosis, 28, 1052-1056.
- Freitas LG, Alpoim, PN, Komatsuzaki, F et al (2013) Preeclampsia: Are Platelet Count and Indices Useful for Its Prognostic? Hematology, 18, 360-364.
- Hoffbrand V, Moss PAH (2016). Essential Haematology. 7th ed. WILLY-BLAKWELL, India, pp 265 – 266.
- Hong H, Xiao W, Maitta RW (2014). Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage. PLoS One. eb5465.
- Järemo P, Lindahl T.L, Lennmarken C, et al. (2000) The Use of Platelet Density and Volume Measurements to Estimate the Severity of Preeclampsia. European Journal of Clinical Investigation, 30, 1113-1118.
- Larsen SB, Grove EL, Hvas AM, Kristensen SD (2014). Platelet turnover in stable coronary artery disease-influence of thrombopietin and low grade inflammation. PLoS One. e85566.
- Narcie H, Turk E, Karagulle E, Togan T, Karabulut K (2013). The of mean platelet volume in the diagnosis of acute appendicitis: a retrospective case-controlled study. Iran Red Crescent Med J. 15E11934.
- Nooh AM, Abdeldayem HM (2015). Changes in Platelet Indices during pregnancy as potential markers for prediction of preeclampsia development. Open Journal Obstetric Gynecology. 5, 703 – 12.
- Obisesan KA, Adeyemo AA, Okunade MA (1998). Haematological values in pregnancy in Ibadan, Nigeria. Afr J Med Sci 27 (1-2): 9-11.
- Pughikumo OC, Pighikumo DT, Iyalla C (2015). Platelet Indices in pregnant women in Port Harcourt, Nigeria. IOSR Journal of Dental and Medical Sciences. 14 (3): 28 – 31.
- Sachdev R, Tiwari AK, Goel S, Rania V, Sethi M (2014). Establishing biological reference interval for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ration, Platelet-X, plateletcrit, and platelet distribution width) and their correlation among each other. Indian Journal Pathol Microbiol. 57: 23 – 15.
- Santos EV, Meirelles FJ (2004). Measurement of platelet parameters in normal and pre-eclamptic pregnant women. Rev Bras Ginecol Obstet, 26 (3): 201-206.
- Thachil J (2015). Platelets in inflammatory disorders: a pathophysiological and clinical perspective. Semi Thromb Hemost. 41: 572 – 81.
- Turgeon ML (2017). Clinical Hematology: theory and procedures. 6th ed. Wolters Kluwer Health. Lippincott Williams and Wilkins, China, pp 654 – 657.
- Valera M, Parant O, Vayssiere C, Arnal JO, Payrastre B (2010). Physiologic and Pathologic changes of platelets in pregnancy. Platelets, 21 (8): 587-595.
- Yong S.W, Cho S.H, Kwon H.S, et al. (2014) Significance of the Platelet Distribution Width as a Severity Marker for the Development of Preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 175, 107-111.
Cite this Article:
International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.