Effects of 6-hydroxydopamine on the Expression of Iron Metabolism - Related Proteins in Primary Oligodendrocyte Progenitor Cells

Author(s): Chen Zhi-qiang, Li Na, Wang Jun

Oligodendrocyte progenitor cells play an important role in the formation of myelin sheath and the protection of neurons. After the action of 6- hydroxy dopamine on primary oligodendrocyte progenitor cells, elevated iron regulatory proteins resulted in an increase in Transferrin Receptor-1 and a decrease in Ferroportin-1 in oligodendrocyte progenitor cells.The extracellular iron entering cells is mediated by TfR1 endocytosis. As the expression of Transferrin Receptor-1 increases, the large number of extracellular iron moves into oligodendrocyte progenitors, but the expression of Ferroportin-1 was decreased, the intracellular iron turnover decreased, increase of iron content in the cell. 6-hydroxydopamine acts on oligodendrocyte progenitor cells leading to changes in intracellular iron metabolism, so that oligodendrocyte progenitor cells increased iron content.

6-hydroxydopamine, Primary Oligodendrocyte Precursor, IRP1, FPN1, TfR1

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