Effects of 6-hydroxydopamine on the Expression of Iron Metabolism - Related Proteins in Primary Oligodendrocyte Progenitor Cells

Effects of 6-hydroxydopamine on the Expression of Iron Metabolism - Related Proteins in Primary Oligodendrocyte Progenitor Cells

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Author(s)

Author(s): Chen Zhi-qiang, Li Na, Wang Jun

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DOI: 10.18483/ijSci.1429 141 467 82-84 Volume 6 - Sep 2017

Abstract

Oligodendrocyte progenitor cells play an important role in the formation of myelin sheath and the protection of neurons. After the action of 6- hydroxy dopamine on primary oligodendrocyte progenitor cells, elevated iron regulatory proteins resulted in an increase in Transferrin Receptor-1 and a decrease in Ferroportin-1 in oligodendrocyte progenitor cells.The extracellular iron entering cells is mediated by TfR1 endocytosis. As the expression of Transferrin Receptor-1 increases, the large number of extracellular iron moves into oligodendrocyte progenitors, but the expression of Ferroportin-1 was decreased, the intracellular iron turnover decreased, increase of iron content in the cell. 6-hydroxydopamine acts on oligodendrocyte progenitor cells leading to changes in intracellular iron metabolism, so that oligodendrocyte progenitor cells increased iron content.

Keywords

6-hydroxydopamine, Primary Oligodendrocyte Precursor, IRP1, FPN1, TfR1

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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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