Effect Of Curcumin On Hematological, Biochemical And Antioxidants Parameters In Schistosoma Mansoni Infected Mice

Effect Of Curcumin On Hematological, Biochemical And Antioxidants Parameters In Schistosoma Mansoni Infected Mice

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Author(s)

Author(s): Essam A. Mahmoud, Ashraf A. Elbessoumy

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1458 2413 1-14 Volume 2 - Mar 2013

Abstract

The present study aims to investigate the effect of curcumin on treatment of schistosoma mansoni infected mice. Sixty mice were used in this experiment were divided equally into four groups ,the first kept as control, the second supplemented with curcumin , the third infected with schistosoma mansoni and the fourth infected and treated with curcumin. Our results emphasized on the presence of anemia, leucopenia , neutropenia and eosinophilia in infected groups either treated or non-treated with an improvement in the treated group. The biochemical parameters; ALT, AST, ALP, total protein, albumin, AFP, TNF- α and lipid profile (TC, TG, HDL-C &LDL-C) improved significantly in infected treated mice compared with infected one. By the same way, results showed an improvement of some anti-oxidant parameters (MAD, GSH, CAT and SOD) in Schistosoma mansoni infected treated mice.

Keywords

Schistosoma mansoni, Curcumin, Erythrocyte, Lucocytes, Liver enzymes, Antioxidant enzymes, Lipid profile

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