Author(s): Shuai Zhang, Zhe Sun, Yuewen Qi, Xiaolu Fang, Hong Yu
Objective: Numerous epidemiological studies have reported the association between silent mating type information regulation 2 homolog-1 (SIRT1) and female reproductive system cancer, but the data of different reports remains controversial. To accurately evaluate the significance of SIRT1 expression in reproductive system cancer, a meta-analysis based on published studies was conducted. Methods: Relevant articles before August 2017 on SIRT1 and reproductive system cancer were searched via PubMed, Embase, Cochrane Central and Chinese National Knowledge Infrastructure databases(NCBI). The studies were chosen for the meta-analysis based on requisite criteria. The overall survival (OS) and clinical features including FIGO stage , lymph node metastasis (LNM) and tumor grade were analyzed using RevMan 5.3 software. Odds ratios (OR) , hazard ratios (HR) and their 95% corresponding confidence intervals (CI) were pooled to estimate the effect of specific associations. Results: A total of 14 eligible studies containing 1002 patients were enrolled, in which 47.9% of the patients overexpressed SIRT1. The results showed that SIRT1 overexpression significantly correlated with the risk of reproductive cancers (OR=3.92, 95% CI: 3.06–5.02, P<0.00001), histological grade (OR=2.47, 95% CI=1.19-5.13, p=0.02), LNM (OR=3.25, 95% CI=1.85-5.70, P<0.0001), but no statistical significance was related to FIGO stage (OR=1.84, 95% CI=1.00-3037, P=0.05) and overall survival (HR=1.32, 95% CI=1.00-1.75, P=0.05) of female reproductive system cancer. Conclusions: The overall data of the shown meta-analysis suggested that the expression of SIRT1 is correlated with cancer risk, lymph node metastasis and histological grade. However, the over-expression of SIRT1 have no statistical significance with FIGO stage and overall survival.
SIRT1, Reproductive System Cancer, Clinicopathological Characteristics, Prognosis, Meta-Analysis
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