Prognostic Value of Hypoxia-Inducible Factor 1α in Solid Malignancies: A Meta-Analysis

Prognostic Value of Hypoxia-Inducible Factor 1α in Solid Malignancies: A Meta-Analysis

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Author(s)

Author(s): Yuewen QI, Shuai Zhang, Zhe Sun, Xiaolu Fang, Hong Yu

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DOI: 10.18483/ijSci.1616 82 306 111-120 Volume 7 - Mar 2018

Abstract

Numerous studies have reported the prognostic role of Hypoxia-Inducible Factor 1α(HIF-1α)and solid malignancies, but the data of different reports remains controversial. To accurately evaluate the prognostic value of HIF-1α expression in solid malignancies, a meta-analysis based on published studies was conducted. Relevant studies from 34 observational articles with 3828 patients were collected via PubMed, Embase. These studies were chosen for the meta-analysis based on requisite criteria and the quality was evaluated using the Newcastle Ottawa Quality Assessment Scale. Hazard ratios (HRs) and 95% confidence interval (CIs) were pooled from studies on overall survival (OS) and disease-free survival (DFS) to estimate the association. The pooled HRs (95% CIs) of HIF-1α for OS and DFS were 1.94 [1.74, 2.16] and 2.16 [1.71, 2.74], respectively. The overall data of the shown meta-analysis suggested that the high expression of HIF-1α is correlated with poor survival outcome in solid malignancies.

Keywords

Hypoxia-Inducible Factor 1α, Prognostic, Solid Malignancies, Meta-Analysis

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