Study on the Effect of LHA on Feeding and its Mechanism

Study on the Effect of LHA on Feeding and its Mechanism

Loading document ...
Page
of
Loading page ...

Author(s)

Author(s): Wang Zhongxiang, Wang Mi, Wang Qian, Sun Xiangrong, Xu Luo

Download Full PDF Read Complete Article

DOI: 10.18483/ijSci.1627 103 284 77-85 Volume 7 - Apr 2018

Abstract

Objective: To study the effect of lateral hypothalamic area on feeding and its specific mechanism. Methods: Intraventricular catheterization was used in rats,GLP-1 receptor agonist Ex4 or GLP-1 receptor antagonist Ex9 were injected into the lateral hypothalamic area (LHA) of rats, and the effects of food intake, water intake, body weight, kaolin intake and high-carbonhydrate diet were observed. Results: Immunohistochemical experiments showed the presence of GLP-1 receptor LHA in rats; When GLP-1 receptor was excited, the 1h and 24 h food intake of rats decreased, and the body weight decreased , and there was no significant change in the kaolin intake in rats; When GLP-1 receptor was blocked, there was no significant change in 24h food intake but weight gain in rats; When GLP-1 receptor was excited, high-carbonhydrate diet significantly reduced but there was no significant change in water intake; When GLP-1 receptor was blocked, high-carbonhydrate diet significantly increased but there was no significant change in water intake. Conclusion: GLP-1 receptor can be involved in the regulation of feeding behavior, and the signal may be related to the hedonicproperties of food.

Keywords

Food intake, GLP-1, LHA

References

  1. Cork SC, Richards JE, Holt MK, et al. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain[J]. MolMetab, 2015, 4(10):718-731
  2. Skibicka KP. The central GLP-1: implications for food and drug reward[J].Front Neurosci, 2013, 7: 181-189
  3. Barrera JG, Jones KR, Herman JP, et al. Hyperphagia and increased fat accumulation in two models of chronicCNS glucagon-like peptide-1 loss of function[J]. J Neurosci,2011, 31: 3904–3913
  4. Rinaman L. Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energyexpenditure[J]. Brain Res,2010, 1350: 18–34
  5. Liu J, Conde K, Zhang P, et al. Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus[J].Neuron, 2017, 96(4):897-909
  6. Alhadeff AL, Rupprecht LE, Hayes MR. GLP-1 neurons in the nucleusof the solitary tract project directly to the ventral tegmental area andnucleus accumbens to control for food intake[J]. Endocrinology, 2012, 153: 647–658
  7. Matsuo R, Kobashi M, Mitoh Y, et al. Role of the lateral hypothalamus in submandibular salivary secretion during feeding in rats. [J]. Brain Res, 2015, 1596: 99-107
  8. Talakoub O, Paiva RR, Milosevic M, et al.Lateral hypothalamic activity indicates hunger and satiety states in humans[J].Ann ClinTranslNeurol, 2017, 4(12):897-901
  9. Risold PY, Swanson LW. Connections of the rat lateral septal complex[J].Brain Res Brain Res Rev, 2017, 24: 115–195
  10. Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon andglucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system[J]. J Comp Neurol, 1999, 403: 261–280
  11. Luo AH, Tahsili-Fahadan P, Wise a R, et al.Linking context with reward: a functional circuit from hippocampal CA3to ventral tegmental area[J]. Science, 2011, 333: 353–357
  12. Iepsen EW, Torekov SS, Holst JJ. Liraglutide for type 2 diabetes and obesity: a2015 update[J]. Expert Rev CardiovascTher, 2015, 13: 753–767
  13. Hayes MR. Neuronal and intracellular signaling pathways mediating GLP-1 energybalance and glycemic effects[J]. PhysiolBehav, 2012, 106: 413–416
  14. Skibicka KP. The central GLP-1: implications for food and drug reward[J]. FrontNeurosci,2013, 7: 181
  15. Finan B, Yang B, Ottaway N, et al. Targetedestrogen delivery reverses the metabolic syndrome[J]. Nat Med, 2012, 18: 1847–1856
  16. SöderpalmAH,Berridge KC. The hedonic impact and intake of foodare increased by midazolam microinjection in the parabrachialnucleus[J]. Brain Res, 2000, 877(2): 288–297
  17. Göke R, Larsen PJ, Mikkelsen JD, Sheikh SP. Distribution of GLP-1binding sites in the rat brain: Evidence that exendin-4 is a ligand of brainGLP-1 binding sites[J]. Eur J Neurosci, 1995, 7: 2294–2300
  18. Kanoski SE, Rupprecht LE, Fortin SM, et al. The role of nausea in food intake and body weight suppression byperipheral GLP-1 receptor agonists, exendin-4 and liraglutide[J]. Neuropharmacology, 2012, 62: 1916–1927
  19. Alhadeff AL, Baird JP, Swick JC, et al. Glucagon-likepeptide-1 receptor signaling in the lateral parabrachial nucleus contributesto the control of food intake and motivation to feed[J]. Neuropsychopharmacology, 2014, 39: 2233–2243

Cite this Article:

  • BibTex
  • RIS
  • APA
  • Harvard
  • IEEE
  • MLA
  • Vancouver
  • Chicago

International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

Search Articles

Issue August 2019

Volume 8, August 2019


Table of Contents


Order Print Copy

World-wide Delivery is FREE

Share this Issue with Friends:


Submit your Paper