Urine Lunx mRNA as a Potential Molecular Diagnostic Tool for Lung Cancer

Urine Lunx mRNA as a Potential Molecular Diagnostic Tool for Lung Cancer

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Author(s): Sanxia Zhao, Yinlin Ge

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DOI: 10.18483/ijSci.1782 78 285 1-3 Volume 7 - Sep 2018


Objective: Exploring the expression of cell-free RNA in urine of normal patients and lung cancer patients, analyze its clinical value in the dignosis of lung cancer. Methods: The urine samples were collected from lung cancer patients and healthy people. Extracted the total cf-RNA from all samples. The contents of total cf-RNA in two groups were detected, and the expressions of LUNX mRNA in two groups were measured by quantitative real-time PCR. Receiver-operating characteristics (ROC) curve was established to evaluate the diagnostic value of urine cf-RNA for the differentiation between lung cancer patients and the control group. Results: Compare to the normal group (50.50±4.527ng), the urinary cf-RNA content in patients (133.8±8.615ng) was significantly increased, p<0.05. The expression of urinary lunx mRNA level from patients was raised, p<0.05. ROC curve analysis showed that, in the diagnosis, AUC value of lunx mRNA was 0.83(95% CI, 0.747-0.906), p<0.05. Conclusion: The expression of urine cf-RNA and Lunx mRNA was elevated, and can be used as a potential molecular diagnostic tool for lung cancer.


Urine, Lung Cancer, cf-RNA, Diagnosis


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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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