Pharmaceutical manufacturing has largely grown in recent years. This and many other factors have led to the ability of manipulating pharmaceutical dosage forms and routes of administration. One example of such unique dosage forms is Fast Dissolving Tablets (FDTs), which are solid dosage forms intended to be dissolved in mouth in a relatively short time, ranging from a few seconds to up to 3 minutes. In this research, ketoprofen was chosen to be the active pharmaceutical ingredient (API) in a fast dissolving tablets formulation, being a model of non-steroidal anti- inflammatory drugs (NSAIDs). Ketoprofen is widely used as an analgesic, and being so, the faster the effect, the better the dosage form. Therefore solid preparation of Ketoprofen with superdisintegrants like Croscarmellose sodium, and/or Crospovidone in different ratios were prepared with a view to increase its effect by decreasing the time required for the drug to be released. The ingredients of the formulation were tested for incompatibles by using IR method; all ingredients were compatible. Ketoprofen and the excipients were mixed together and submitted to pre-formulation tests. The powders were then compressed into tablets by direct compression method. The prepared batches of tablets were evaluated for hardness, friability, disintegration time, wetting time and in-vitro drug release which tested in comparing with Profenid®. Ketoprofen FDTs prepared showed better results than Profenid® depending on dissolution test. Formula no.5 and no.10 showed the best disintegration times of 30 seconds, and maximum drug release from Formula No 3, 4, 5, 10 about 98% in 2 minutes.
Fast Dissolving Tablets, Ketoprofen, Superdisintegrants, Direct Compression
- Yash Paul, Sarvan Tyagi and Bhupinder Singh, Formulation and Evaluation of Oral Dispersible Tablets of Zidovudine with different Superdisintegrants. International journal of current pharmaceutical review and research- volume 2, issue 2, May - July 2011.
- Sehgal Prateek et al. (2012). Fast Dissolving Tablets: A New Venture in Drug Delivery. Am. J. PharmTech Res. ; 2(4)
- Mahajan Anil Arun (2011). Formulation and evaluation of fast dissolving tablets of ketoprofen- Master dissertation. Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore.
- Fu Y, Yang S, Jeong S.H., Kimura S, Park K. Orally fast disintegrating tablets: Development, technologies, taste-masking and clinical studies. Crit Rev Ther Drug Carrier Sys, 2004; 21:433-76.
- Nayak AK, Manna K. Current developments in orally disintegrating tablet technology. Journal of Pharmaceutical Education and Research. 2011;2(1):21–34.
- GOPAL.V et al. (2011). Formulation, design and evaluation of orally disintegrating tablets of loratadine using direct compression process. International Journal of Pharma and Bio Sciences -Vol 2, Issue 2: 389- 400.
- Nikam et al. (2011). Mouth dissolving tablets: an overview. Pharmacologyonline 3: 562-58.
- Tiwari et al. (2013), Formulation and Evaluation of Faast Dissolving Tablets, IJARPB: 3 (1), 60 – 69.
- R. V. Keny, Chrisma Desouza, and C. F. Lourenco. (2010). Formulation and Evaluation of Rizatriptan Benzoate Mouth Disintegrating Tablets. Indian J Pharm Sci.; 72(1): 79–85
- British Pharmacopoeia. (2013) .Volume I & II :Ketoprofen. Ph. Eur. monograph 0922.
- Khan, J., Yuen, K.H., Bee Hong, N., Chitneni, M., Elhassan, G.O., Al-Dhali, S., & Kaleemullah, M. (2010). Preparation and In-vitro Evaluation of Different Controlled Release Polymeric Matrices Containing Ketoprofen. HealthMED, Vol. 4(2), 386-392.
- USP. <616> Bulk density and tapped density. USP30 NF 25 (2007)
- Hausner H. H(1967). Friction conditions in a mass of metal powder. Int. J. Powder Metall. ;3:7–13.
- Carr R. L(1965). Evaluating flow properties of solids. Chem. Eng. ;72:69–72.
- SIVAKRANTH. M et.al. (2011). formulation and evaluation of oral fast dissolving tablets of sildenafil citrate. International Journal of Pharmacy and Pharmaceutical Sciences. Vol 3, Suppl 2, 2011.
- M.E. Aulton. Pharmaceutics, the science of dosage form design, second edition. Churchill Livingstone. (2002); p-114.
- S. Basavaraj et.al. (2008). .; Development and Characterization Of Orodispersible Tablets of Famotidine Containing a Subliming Agent , Trop . J. Pharm. Res., 7(4):1185-1189.
- AL- Buryhi,M,M; Doctor Thesis , Faculty Of Pharmacy , Cairo University , (2009).
- Bolourtchian et.al. (2008). Formulation and Optimization of Captopril Sublingual Tablet Using D-Optimal Design , IJPR ; 7 (4) : 259- 267.
- Singh, Jashanjit , Singh, and Rajmeet. (2009). Optimization and Formulation of Orodispersible Tablets of Meloxicam , Trop. J. Pharm. Res., 8(2):153-159.
- M. Vikram et.al. (2009). Formulation, Characterization ,and Optimization Of Fast- Dissolve Tablets Containing Celecoxib Solid Dispersion ,Dissolution Technologies.
- Bompilwar MS, Gawai NM and Biyani KR. (2013). Formulation and Evaluation of Orodispersible Tablet of Metformin HCl. International Journal of Research in Pharmaceutical and Biomedical Sciences. Vol. 4 (3) Jul– Sep 2013.
- Sheetal Malke, Supriya Shidhaye, VJ Kadam. (2007). Formulation and evaluation of oxcarbazepine fast dissolve tablets. Indian journal of pharmaceutical sciences. Volume : 69, Issue : 2, Page : 211-214
- Raymond C Rowe, Paul J Sheskey, Marian E Quinn. (2009). Handbook of Pharmaceutical Excipients. 6th edition. Pharmaceutical Press, UK. p-(206-208), 208-210, 581-585, 129-133, 404-407, 728-731, 424-428, 679-682, 48-50, 86-89, 185-18).
- Juanita Tanuwijaya and Karsono, The Effects of Crospovidone and Croscarmellose Sodium as Superdisintegrants on the Characteristics of Piroxicam Nanoparticles ODT (Orally Disintegrating Tablet), IJPRIF, Vol.5, No.4, pp 1590-1597, Oct-Dec 2013.
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