MPP+ Attenuates the Inhibition of p53 by Parkin in SH-SY5Y Cells

MPP+ Attenuates the Inhibition of p53 by Parkin in SH-SY5Y Cells

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Author(s): Yanmin Zhong

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DOI: 10.18483/ijSci.1967 27 172 10-12 Volume 8 - Apr 2019


Parkin acts as a p53 transcriptional repressor, binds to p53 gene promoter in the nucleus, thereby inhibiting the transcription of p53 gene. However, whether this process take part in Parkinson's disease (PD) is unclear. In order to detect the inhibitory effect of parkin on p53 in the PD model, parkin-transfected SH-SY5Y cells were treated with 1-methyl-4-phenylpyridinium (MPP+). The results showed that parkin could inhibit the expression of p53 protein under physiological conditions, but in the PD cell model, the function of parkin impaired, which reduced the inhibitory function of p53.


Parkin, p53, Parkinson's Disease


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