Study on the Release of Vancomycin-Loaded Calcium Sulphate by Three-Dimensional Printing in Vitro

Author(s): Qian Zhang, Huailong Sun

Objective: To prepare a three-layer cylindrical drug carrier with different drug concentration in each layer by using 3D printing technology, and compare it with the drug carrier prepared by ordinary mold to discuss the drug release rules of the two groups of carriers. Methods：the experimental group was the three layers of cylindrical calcium sulfate carrier prepared by the 3D printer, vancomycin content is different, each layer from top to bottom respectively contain vancomycin 25 mg, 50 mg, 25 mg, compared with vancomycin and calcium sulfate by mould preparation after mixing , each contain vancomycin 100 mg，two groups of total content of vancomycin was same, Soak in 5 ml PBS buffer after drying, respectively at 1, 3, 5, 7, 10, 14, 18, 22, 26, 30day point in time, detection of drug release from two groups of carriers ,and discuss the drug release rule of two groups. Results: The drug release of the experimental group was more stable than that of the control group. Conclusion: The release effect of sustained release vector prepared by 3D printing is better than that prepared by ordinary mold.

3D Printing, Infectious Bone Defect, Vancomycin-Loaded Calcium Sulphate, Sustained-Release Vector

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