Changes of Learning and Memory Ability in fos-GFP Transgenic Mice

Author(s): Chen W, Cao HaiS, Sun XiaoM

Objective To study the changes of learning and memory ability in fos-GFP transgenic mice. Methods The mice in the fos-GFP group and the control were tested by using overhead cross maze,open field,and Morris Water Maze[1]. The spontaneous activity,anxiety state,the ability of learning and memory were tested as well. Results The differences between fos-GFP mice and the control were not significant in terms of distance of motion within the field,velocity,duration of stay at the marginal zone,and duration of open arm in the maze(p>0.05).The difference between the mice in the two groups was not significant with regard to latency of finding the flat at each time point(p>0.05),and the percentage of duration in target quadrant in Morris Water Maze(p>0.05),and similar freezing time in contextual fear conditioning test(p>0.05).The fos-GFP mice showed higher freezing level than normal controls in no-exposed fear conditioning(t=9.48,P<0.001). Conclusion The ability of hippocampus-dependent associative learning and memory in fos-GFP transgenic mice was somewhat improved.

fos-GFP Fused Protein, Learning, Memory, Neurobehavioral Manifestations, Mice

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