Introduction: Erectile dysfunction (ED) is the most common cause of sexual dysfunction in men and shares several risk factors with systemic conditions, such as cardiovascular disease and metabolic syndrome (MetS). Objective: Investigate the relationship between ED and MetS among patients at a university hospital. Patients and Methods: Patients with ED were retrospectively investigated in a cross-sectional study conducted at a university hospital. The following variables were analyzed: systemic arterial hypertension, type 2 diabetes mellitus (DM2), dyslipidemia, obesity, smoking, alcohol use, low adherence to treatment or ineffective treatment, medications, glycated hemoglobin and lipids (total cholesterol, HDL and triglycerides). Results: Among the 96 patients studied, 23 (24%) met the criteria for MetS. Analyzing only one comorbidity, 10.4% of patients had hypertension, 5.2% had DM2 and 5.2% had dyslipidemia. Age ranged from 21 to 78 years (mean: 56.9 ± 12.2 years) and 52% of patients were older than 60 years of age. Abnormal glycated hemoglobin was found in 40.6%) of patients; 41.6% had dyslipidemia; 47.9% had hypertension; and 39.6% used anti-hypertensive medications. Smoking was found in 39.5% and alcohol use was found in 30.2%. The results of the chi-squared test revealed that smoking was significantly associated with hypertension, DM2 and dyslipidemia (P < 0.01). Nearly half (46.9%) of the patients had low adherence or underwent ineffective treatment. Conclusion: No association was found between erectile dysfunction and metabolic syndrome. Significant associations were found between smoking and hypertension, DM2 and dyslipidemia.
- Montorsi P, Ravagnani PM, Vlachopoulos C. Clinical significance of erectile dysfunction developing after acute coronary event: exception to the rule or confirmation of the artery size hypothesis? Asian J Androl 2015;17(1):21-5.
- Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013;381:153–165.
- NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA. 1993;270(1):83–90.
- Melman A. Evaluation and management of erectile dysfunction. Surg Clin North Am 1988;68(5):965-81.
- Mulcahy JJ. Current approach to the treatment of penile implant infections. Ther Adv Urol 2010;2(2):69-75.
- Heidler S, et al. Is the metabolic syndrome an independent risk factor for erectile dysfunction? J Urol 2007;177:651–654.
- Jackson G. The metabolic syndrome and erectile dysfunction: multiple vascular risk factors and hypogonadism. Eur Urol 2006;50:426–427.
- Kubin M, Wanger G, Fugl-Meyer AR. Epidemiology of erectile dysfunction. Int J Impot Res 2003;15:63-71.
- Expert Panel on Detection, E. and Treatment & Adults, o. H. B. C. i Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
- Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Clinical review: Prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review. J Clin Endocrinol Metab 2009; 94:1853–1878.
- Santos Ce, Schrank Y, Kupfer R. Análise crítica dos critérios da OMS, IDF e NCEP para síndrome metabólica em pacientes portadores de diabetes melito tipo 1. Arq Bras Endocrinol Metab 2009;53(9):1096-1102.
- Kapur V, Schwarz ER. The relationship between erectile dysfunction and cardiovascular disease. Part I: pathophysiology and mechanisms. Rev Cardiovasc Med 2007;8(4):214-9.
- El-Sakka AI, Morsy AM, Fagih BI. Severity of erectile dysfunction could predict left ventricular diastolic dysfunction in patients without overt cardiac complaint. J Sex Med 2011;8(9):2590-7.
- Sivalingam S, Hashim H, Schwaibold H. An overview of the diagnosis and treatment of erectile dysfunction. Drugs 2006;66(18):2339-55.
- El-Sakka AI, Morsy AM, Fagih BI, Nassar AH. Coronary artery risk factors in patients with erectile dysfunction. J Urol 2004;172(1):251-4.
- Francavilla S, Bocchio M, Pelliccione F, Necozione S, Francavilla F. Vascular aetiology of erectile dysfunction. Int J Androl 2005;28 Suppl 2:35-9.
- Brunner H, Cockcroft Jr, Deanfield J, Donald A, Ferrannini E, Halcox J, et al. Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005;23(2):233-46.
- Gazzaruso C, Giordanetti S, De Amici E, Bertone G, Falcone C, Geroldi D, et al. Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients. Circulation 2004;110(1):22-6.
- Mulhall J, Teloken P, Brock G, Kim E. Obesity, dyslipidemias and erectile dysfunction: a report of a subcommittee of the sexual medicine society of North America. J Sex Med 2006;3(5):778-86.
- Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, Briganti A, et al. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. Eur Heart J 2006;27(22):2632-9.
- Sekoranja L, Bianchi-Demicheli F, Gaspoz JM, Mach F. Erectile dysfunction: a potential useful marker for cardiovascular disease. Rev Med Suisse 2006;2(58):774-6, 78.
- Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med 2011;171(20):1797-803.
- Canat L, Cicek G, Atis G, Gurbuz C, Caskurlu T. Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction? Int Braz J Urol 2013;39(4):465-73.
- Sai Ravi Shanker A, Phanikrishna B, Bhaktha Vatsala Reddy C. Association between erectile dysfunction and coronary artery disease and its severity. Indian Heart J 2013;65(2):180-6.
- Meller SM, Stilp E, Walker CN, Mena-Hurtado C. The link between vasculogenic erectile dysfunction, coronary artery disease, and peripheral artery disease: role of metabolic factors and endovascular therapy. J Invasive Cardiol 2013;25(6):313-9.
- Spessoto LC, Cordeiro JA, Godoy JMG. Effect of systemic arterial pressure on erectile dysfunction in the initial stages of chronic arterial insufficiency. BJU Int 2010;11:1723-5.
- Kaya E, Sikka SC, Gur S. A comprehensive review of metabolic syndrome affecting erectile dysfunction. J Sex Med 2015;12:856–875.
- Sanchez-Cruz, J. J., Cabrera-Leon, A., Martın-Morales, A., Fernandez, A., Burgos, R., Rejas, J. Male erectile dysfunction and health-related quality of life. Eur Urol 2003;44: 245–253.
- Sanjay S, Bharti GS, Manish G, Rajeev, P, Pankaj, A, Puspalata, A, et al. Metabolic syndrome: An independent risk factor for erectile dysfunction. Indian J Endocrinol Metab 2015;19(2):277-82.
- Hatzimouratidis, K., Giuliano, F., Moncada, I., Muneer, A., Salonia, A., Verze, P. EAU guidelines on erectile dysfunction, premature ejaculation, penile curvature and priapism. Eur Assoc Urol 2016;46.
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