Objective To study the preventive effect of ginsenoside Rg1 on posttraumatic stress disorder (PTSD) in mice. Methods Single prolonged stress (SPS) animal model was adopted. Mice treated with normal saline, ginsenoside (Rg1) and sertraline after stress were divided into negative control group(SPS+NS), experimental group(SPS+Rg1) and positive control group(SPS+Sertraline) respectively, and a blank control group(NS) was set. On the 8th and 10th days after modeling, the viaduct cross maze experiment and the forced swimming experiment were respectively carried out. Results In the elevated plus maze experiment, the percentage of opening times of mice in the experimental group and the negative control group [(21.11±7.21) %, (20.80±9.06) %] was significantly lower than that in the blank control group and the positive control group [(44.99±7.69) %, (39.35±14.14) %,P < 0.0001].In the forced swimming experiment, the immobility time of mice in the experimental group and the negative control group [(64.05±24.27) s, (51.23±19.76) s] was significantly higher than that in the blank control group and the positive control group [(16.85±6.90) s, (33.26±20.30) s, P < 0.001]. Conclusion The normal dose of ginsenoside Rg1 could not alleviate the anxiety and fear responses in the mice with post-traumatic stress disorder.
Ginsenoside, Post-Traumatic Stress Disorder, Single Prolonged Stress
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