Research Progress of Antitumor Activity by Baicalin and Baicalein

Research Progress of Antitumor Activity by Baicalin and Baicalein

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Author(s)

Author(s): Wang Yu, Li Ling

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DOI: 10.18483/ijSci.2099 9 21 11-14 Volume 8 - Jun 2019

Abstract

Baicalin and its aglycon, baicalein, are flavonoids present from Scutellaria baicalensis Georgi. Baicalin generally inhibits tumor cells by inducing apoptosis and arresting growth, while baicalein suppresses by regulating autophagy. Certain signaling pathways and regulating factors are involved among the induced-apoptosis and autophagy progress. In suppressing growth, baicalin and baicaein inhibit angiogenesis or induce cell cycle arrest at S phase against proliferation, migration and differentiation. The present agents against tumor still have related side effects. Therefore, the natural and nontoxic flavonoids are promising in present even future tumor treatment.

Keywords

Antitumor, Baicalin, Baicalein

References

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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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