The cystic fibrosis is genetic disease characterised by build-up of thick mucus in the lungs, which causes difficulties in breathing. It is caused by mutations in CFTR protein. Here, we utilised the Resonant Recognition Model (RRM), which proposes that proteins specific activity is characterised by specific frequencies (wavelengths) of electromagnetic radiation. Using the RRM approach, we have identified the electromagnetic frequency (wavelength) characterising the healthy CFTR proteins, while the amplitude at this frequency is diminishing in mutated CFTR proteins. Thus, the identified characteristic frequency (wavelength) for heathy CFTR proteins could be proposed to be critical for healthy functioning of CFTR proteins and for differentiating between healthy and malfunctioning CFTR proteins related to cystic fibrosis. In addition, using the RRM approach we achieved the possible explanation on how specific temperature of 27-28°C can restore the healthy function in mutated CFTR proteins.
Protein Electromagnetic Resonances, Cystic Fibrosis, CFTR Proteins, Resonant Recognition Model, Molecular Modelling
- Cosic I: Macromolecular Bioactivity: Is it Resonant Interaction between Macromolecules? -Theory and Applications. IEEE Trans on Biomedical Engineering, 1994, 41, pp. 1101-1114.
- Cosic I: Virtual spectroscopy for fun and profit. Biotechnology, 1995, 13, pp. 236-238.
- Cosic I: The Resonant Recognition Model of Macromolecular Bioactivity: Theory and Applications. Basel: Birkhauser Verlag, 1997.
- Pirogova E, Cosic I: Examination of amino acid indexes within the Resonant Recognition Model. Proc. of the 2nd Conference of the Victorian Chapter of the IEEE EMBS, 2001, pp. 124-127.
- Cosic I, Cosic D, Lazar K: Analysis of Tumor Necrosis Factor Function Using the Resonant Recognition Model. Cell Biochemistry and Biophysics, 2015, 11, doi: 10.1007/s12013-015-0716-3.
- Cosic I, Lazar K, Cosic D: Cellular Ageing - Telomere, Telomerase and Progerin analysed using Resonant Recognition Model. MD-Medical Data, 2014, 6(3), pp. 205-209.
- Krsmanovic V, Biquard JM, Sikorska-Walker M, Cosic I, Desgranges C, Trabaud MA, Whitfield JF, Durkin JP, Achour A, Hearn MT: Investigation into the Cross-reactivity of Rabbit Antibodies Raised against Nonhomologous Pairs of Synthetic Peptides Derived from HIV-1 gp120 proteins. J. Peptide Res, 1998, 52(5), pp. 410-412.
- Cosic I, Lazar K, Cosic D: Prediction of Tubulin resonant frequencies using the Resonant Recognition Model (RRM). IEEE Trans. on NanoBioscience, 2015, 12, pp. 491-496, doi: 10.1109/TNB.2014.2365851.
- Cosic I, Cosic D, Lazar K: Is it possible to predict electromagnetic resonances in proteins, DNA and RNA? Nonlinear Biomedical Physics, 2015, 3, doi: 10.1140/s40366-015-0020-6.
- Cosic I, Cosic D, Lazar K: Environmental Light and Its Relationship with Electromagnetic Resonances of Biomolecular Interactions, as Predicted by the Resonant Recognition Model. International Journal of Environmental Research and Public Health, 2016, 13(7), pp. 647, doi: 10.3390/ijeprh13070647.
- Cosic I, Cosic D: The Treatment of Crigler-Najjar Syndrome by Blue Light as Explained by Resonant Recognition Model. EPJ Nonlinear Biomedical Physics, 2016, 4(9), doi: 10.1140/epjnbp/s40366-016-0036-6.
- Vojisavljevic V, Pirogova E, Cosic I: The Effect of Electromagnetic Radiation (550nm-850nm) on I-Lactate Dehydrogenase Kinetics. Internat J Radiat Biol, 2007, 83, pp. 221-230.
- Dotta BT, Murugan NJ, Karbowski LM, Lafrenie RM, Persinger MA: Shifting wavelength of ultraweak photon emissions from dying melanoma cells: their chemical enhancement and blocking are predicted by Cosic’s theory of resonant recognition model for macromolecules. Naturwissenschaften, 2014, 101(2), doi: 10.1007/s00114-013-1133-3.
- Murugan NJ, Karbowski LM, Persinger MA: Cosic’s Resonance Recognition Model for Protein Sequences and Photon Emission Differentiates Lethal and Non-Lethal Ebola Strains: Implications for Treatment. Open Journal of Biophysics, 2014, 5, pp. 35.
- Karbowski LM, Murugan NJ, Persinger MA: Novel Cosic resonance (standing wave) solutions for components of the JAK-STAT cellular signalling pathway: A convergence of spectral density profiles. FEBS Open Bio, 2015, 5, pp. 245-250.
- Pirogova E, Istivan T, Gan E, Cosic I: Advances in methods for therapeutic peptide discovery, design and development, Current Pharmaceutical Biotechnology. Bentham Science Publishers Ltd, Netherlands ISSN: 1389-2010, 2011, 12(8), pp. 1117-1127.
- Cosic I, Pirogova E: Bioactive Peptide Design using the Resonant Recognition Model. Nonlinear Biomedical Physics, 2007, 1(7), doi: 10.1186/1753-4631-1-7.
- Cosic I, Drummond AE, Underwood JR, Hearn MTW: In vitro inhibition of the actions of basic FGF by novel 16 amino acid peptides. Molecular and Cellular Biochemistry, 1994, 130, pp. 1-9.
- Hearn MTW, Biquard JM, Cosic I, Krsmanovic V: Peptides Immunologically related to proteins expressed by a viral agent, having a sequence of amino acids ordered by means of protein informational method. US Patent 6, 294, 174, 2001.
- Achour A, Biquard JM, Krsmanovic V, M’Bika JP, Ficheux D, Sikorska M, Cozzone AJ: Induction of Human Immunodeficiency Virus (HIV-1) Envelope Specific Cell-Mediated Immunity by a Non-Homologus Synthetic Peptide. PLoS ONE, 2007, 11, pp. 1-12, doi: 10.1371/journal.pone.0001214.
- Pirogova E, Istivan T, Gan E, Cosic I: Advances in Methods for Therapeutic Peptide Discovery, Design and Development. Current Pharmaceutical Biotechnology, 2011, 12, pp. 1117-1127.
- Almansour N, Pirogova E, Coloe P, Cosic I, Istivan T: Investigation of cytotoxicity of negative control peptides versus bioactive peptides on skin cancer and normal cells: a comparative study. Future Medicinal Chemistry, 2012, 4(12), pp. 1553-1565.
- Istivan T, Pirogova E, Gan E, Almansour N, Coloe P, Cosic I: Biological effects of a De Novo designed myxoma virus peptide analogue: Evaluation of cytotoxicity on tumor cells. Public Library of Science (PLoS) ONE, 2011, 6(9), pp. 1-10.
- Cosic I, Hearn MTW: "Hot Spot" Amino Acid Distribution in Ha-ras Oncogene Product p21: Relationship to Guanine Binding Site. J. Molecular Recognition, 1991, 4, pp. 57-62.
- Cosic I, Hearn MTW: Studies on Protein-DNA Interactions Using the Resonant Recognition Model: Application to Repressors and Transforming Proteins. Eur. J. Biochem, 1992, 205, pp. 613-619.
- Cosic I, Hodder AN, Aguilar MI, Hearn MTW: Resonant Recognition Model and protein topography: model studies with myoglobin, haemoglobin and lysozyme. Eur. J. Biochem, 1991, 198, pp. 113-119.
- Caceres JLH, Cosic I, Cosic D: Application of The Resonant Recognition Model to The Study of Plasmodium Proteins Involved in Malaria Infection. MD-Medical Data, 2015, 7(1), pp. 007-014.
- Schmier S, Mostafa A, Haarmann T, Bannert N, Ziebuhr J, Veljkovic V, Dietrich U, Pleschka S: In silico prediction and experimental confirmation of HA residues conferring enhanced human receptor specificity of H5N1 influenza A viruses. Scientific Reports, 2015, 5, doi: 10.1038/srep11434.
International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.