Synthesis and Antibacterial Activity of Ursolic Acid Derivatives

Synthesis and Antibacterial Activity of Ursolic Acid Derivatives

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Author(s): Xiaoyuan Song, Junfang Li, Yimin Wang, Ganjun Yuan, Shan Lai, Houqin Yi, Pingyi Li

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DOI: 10.18483/ijSci.2169 49 129 20-23 Volume 8 - Sep 2019


To obtained natural products with remarkable antibacterial activities, three 3-amino substituted (UA) derivatives 2, 3 and 4 were designed and synthesized, and their antibacterial activity were assayed using broth microdilution method. Compared to UA, there three derivatives present higher antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) with the minimum inhibitory concentrations of 16 to 32 μg/mL. Furthermore, their cytotoxicities to human hepatoma cell (BEL-7402) were evaluated using MTT method, and the results indicated that their derivatives had no toxicity (IC50 value was larger than 10 μM), while UA presented a certain cytotoxicity.


Ursolic Acid, Antibacterial Activity, Synthesis, Structural Modification, Mic, Mtt


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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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