Objective: In the present study the ethanolic extracts of Desmodium triflorum (ETDT), Allmonia nodiflora (ETAN) and Digeria muricata (ETDM) were studied for Aldose reductase, alpha (α)- amylase and alpha (α)-glucosidase inhibition using an in-vitro antidiabetic model. Methods: The serial extraction was carried out with a series of solvents: Petroleum ether, ethyl acetate and ethanol with increasing polarity using Soxhlet apparatus. The concentrated and dried extracts were subjected to the antidiabetic activity was assessed by employing standard in-vitro techniques. Result: The result showed ethanolic extract exhibited significant aldose reductase, α-amylase and α-glucosidase inhibitory activities with an all plant extracts respectively and well compared with standard acarbose drug. This knowledge will be useful in finding more potent antidiabetic principle from the natural resources for the clinical development of antidiabetic therapeutics. Conclusion: The investigation confirms that ethanolic extract exhibited highest antidiabetic activity among all extracts, Additional studies on needed for purification, characterization and structural elucidation of bioactive compounds from ethanolic extract & also confirm its antidiabetic property by in vivo studies. This study provides scientific evidence that leaves of Desmodium triflorum, Allmonia nodiflora and Digeria muricata have anti-diabetic efficacy. Thus, considering its relative hypoglycemic potency, they may serve as useful therapeutic agents for treating diabetes.
In-vitro Antidiabetic, Aldose Reductase, α-Amylase, α-Glucosidase
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