Analysis of Delta (Indian) Variant of SARS-CoV-2 Infectivity using Resonant Recognition Model

Analysis of Delta (Indian) Variant of SARS-CoV-2 Infectivity using Resonant Recognition Model

Loading document ...
Page
of
Loading page ...

Author(s)

Author(s): Irena Cosic, Drasko Cosic, Ivan Loncarevic

Download Full PDF Read Complete Article

DOI: 10.18483/ijSci.2495 19 48 6-11 Volume 10 - Jul 2021

Abstract

This manuscript is continuation of our previous work, where we have analyzed different variants of SARS-CoV-2 virus (UK, South African, Brazilian, and Indian (Kappa)) using Resonant Recognition Model (RRM), which is biophysical model capable to analyze protein function and interaction. We have previously identified correlation between infectivity of these SARS-CoV-2 virus variants with strength of signal at RRM characteristic frequencies for each variant. Here, we have extended this analysis for Delta (Indian) SARS-CoV-2 virus variant, which is extremely infectious and is rapidly spreading around the World. Our results with Delta (Indian) variant are in complete agreement with our previous RRM proposition that viral infectivity is proportional to strength of signal at RRM characteristic frequency. These results can explain why Delta (Indian) variant is more infectious. With strong correlation obtained in all these examples, we can propose here that RRM model can be used as general tool to analyze infectivity of mutated virus variants.

Keywords

Delta Variant of SARS-CoV-2, Prediction of Infectivity, Resonant Recognition Model, COVID-19

References

  1. Cosic I: Macromolecular Bioactivity: Is it Resonant Interaction between Macromolecules? -Theory and Applications. IEEE Trans on Biomedical Engineering, 1994; 41, 1101-1114.
  2. Cosic I: The Resonant Recognition Model of Macromolecular Bioactivity: Theory and Applications. Basel: Birkhauser Verlag, 1997.
  3. Cosic I, Cosic D, Loncarevic I: RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2. MDPI Appl. Sci., 2020; 10, 4053, doi: 10.3390/app10114053.
  4. Cosic I, Cosic D, Loncarevic I: Analysis of UK and South African Strains of SARS-CoV-2 Using Resonant Recognition Model. International Journal of Sciences, 2021, 10(3), 19-25, doi: 10.18483/ijSci.2459.
  5. Cosic I, Cosic D, Loncarevic I: Analyses of Mutated SARS-CoV-2 Variants Using Resonant Recognition Model. Research Gate, Apr 2021; doi: 10.13140/RG.2.2.22747.28969.
  6. CDC: SARS-CoV-2 Variant Classifications and Definitions. Center for Disease Control and Prevention Report, 29 June 2021.
  7. Cosic I: Resonant Recognition Model of Protein-Protein and Protein-DNA Recognition, in Bioinstrumentation and Biosensors. Marcel Dekker Inc New York, 1990; 475-510.
  8. Cosic I, Cosic D, Lazar K: Analysis of Tumor Necrosis Factor Function Using the Resonant Recognition Model. Cell Biochemistry and Biophysics, 2015; doi: 10.1007/s12013-015-0716-3.
  9. Cosic I, Cosic D: Macromolecular Resonances. In: Bandyopadhyay A., Ray K. (eds) Rhythmic Oscillations in Proteins to Human Cognition. Studies in Rhythm Engineering. Springer, Singapore, 2021; 1, 11-45, doi: 10.1007/978-981-15-7253-1_1.
  10. Cosic I, Paspaliaris V, Cosic D: Analysis of Protein-Receptor on an Example of Leptin-Leptin Receptor Interaction Using the Resonant Recognition Model. Appl. Sci., 2019; 9, 5169, doi: 10.3390/app9235169.
  11. Cosic I, Cosic D, Loncarevic I: New Concept of Small Molecules Interaction with Proteins – An Application to Potential COVID-19 Drugs, International Journal of Sciences, 2020; 9(9), 16-25, doi: 10.18483/ijSci.2390.
  12. Krsmanovic V, Biquard JM, Sikorska-Walker M, Cosic I, Desgranges C, Trabaud MA, Whitfield JF, Durkin JP, Achour A, Hearn MT: Investigation Into the Cross-reactivity of Rabbit Antibodies Raised against Nonhomologous Pairs of Synthetic Peptides Derived from HIV-1 gp120 proteins, J.Peptide Res, 1998; 52(5), 410-412.
  13. Hearn MTW, Biquard JM, Cosic I, Krsmanovic V: Peptides Immunologically related to proteins expressed by a viral agent, having a sequence of amino acids ordered by means of protein informational method, US Patent 6, 294, 174, 2001.
  14. Achour A, Biquard JM, Krsmanovic V, M’Bika JP, Ficheux D, Sikorska M, Cozzone AJ: Induction of Human Immunodeficiency Virus (HIV-1) Envelope Specific Cell-Mediated Immunity by a Non-Homologus Synthetic Peptide, PLoS ONE, 2007; 11, 1-12, doi: 10.1371/journal.pone.0001214.
  15. Li F: Receptor recognition and cross-species infections of SARS coronavirus. Antiviral Research, 2013; 100(1), 246–54, doi: 10.1016/j.antiviral.2013.08.014.
  16. Xu X, Chen P, Wang J, Feng J, Zhou H, Li X et al.: Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Science China. Life Sciences, 2020; 63 (3), 457–460, doi: 10.1007/s11427-020-1637-5.
  17. Millet JK, Whittaker G.R. Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells. Virology, 2018; 517, 3–8. doi: 10.1016/j.virol.2017.12.015.
  18. Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X: Structure of SARS-CoV-2 Spike Receptor-Binding Domain Bound to ACE2 Receptor. Nature, 2020; doi: 10.1038/s41586-020-2180-5.

Cite this Article:

International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

Search Articles

Issue August 2021

Volume 10, August 2021


Table of Contents



World-wide Delivery is FREE

Share this Issue with Friends:


Submit your Paper