Therapeutic Effects of Kv7 Channel Activator Retigabine against Seizures and Neurodegeneration in Kainic Acid-Induced Seizure Model

Therapeutic Effects of Kv7 Channel Activator Retigabine against Seizures and Neurodegeneration in Kainic Acid-Induced Seizure Model

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Author(s): Xiao-fei Zhuang

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DOI: 10.18483/ijSci.2598 12 66 9-14 Volume 11 - Jul 2022


Aims: The current study evaluates whether Kv7 channel activator retigabine (RTG) could attenuate seizures and hippocampal neurodegeneration in the kainic acid (KA) induced seizure model. Methods: The anticonvulsant activity of RTG is evaluated by electroencephalography (EEG) recordings in KA-kindled rats. Tunel assay and immunofluorescence of NeuN are used to evaluate the neuroprotective effect of RTG in the hippocampus of KA-kindled rats. Results: RTG effectively reduces epileptiform discharges induced by KA injection. Tunel assay and immunofluorescence of NeuN show that RTG exerts neuroprotection in the hippocampus of KA-kindled rats. Conclusion: Taken together, this study demonstrates that RTG effectively alleviates seizures and hippocampal neurodegeneration in the KA-induced seizure model.


Kv7 Channel, RTG, Kainic Acid, Neuroprotection, Seizure


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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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