As part of the NapolÃ©on I Genome (NIG) project we have reconstructed, based on more than one hundred Y-STRs (Y-short tandem repeats), the complete Y-haplotype of the non-recombinant part of the Y-chromosome (NRY) of French Emperor NapolÃ©on I (1769-1821). We already knew the allelic values at Y-markers of the Y-chromosome of NapolÃ©on I, but only for the palindromic STR YCAIIa and b and for the non-palindromic Y-STR DYS19. The present reconstruction aims to compare the allelic values at Y-STRs of the DNA of Charles NapolÃ©on (C.N.), the living 4th generation descendant of JÃ©rÃ´me Bonaparte (NapolÃ©on Iâ€™s youngest brother), with those of Alexandre Colonna Walewski (A.C.W.), the living 4th generation descendant of Count Alexandre Walewski (the son born of the union between NapolÃ©on I and Countess Maria Walewska). We have previously established that NapolÃ©on I, C.N. and A.C.W. are of the same Y-haplogroup E1b1b1b2a1. The allelic values for C.N. and A.C.W. are the same for ninety-three other non-palindromic markers (belonging to ninety different STRs) and for thirty-eight other palindromic markers (belonging to fifteen different STRs); these values then constitute those deduced in the reconstruction of the allelic values of the STR markers of the NapolÃ©on Iâ€™s Y-haplotype. Four non-palindromic STRs and two palindromic STRs have different allelic values in C.N. and A.C.W.; we have deduced the allelic value of NapolÃ©on I for one (DYS454), and the probable allelic values for two (Y-GATA-C4 and DYS712) of these non-palindromic variable STRs. To sum up, we have established, by reconstruction of the lineage, the allelic values of the markers of NapolÃ©on Iâ€™s Y-haplotype for a total of one-hundred and thirty-three different Y-STR markers.
Y-chromosome haplotype, NapolÃ©on the First, short tandem repeats
- Jehaes E, Pfeiffer H, Toprak K, Decorte R, Brinkmann B, Cassiman JJ: Mitochondrial DNA analysis of the putative heart of Louis XVII, son of Louiss XVI and Marie-Antoinette. Eur J Hum Genet 2001, 9, 185-190
- Lalueza-Fox C, Gigli E, Bini C, Calafell F, Luiselli D, Plotti S, Pettener D: Genetic analysis of the presumptive blood from Louis XVI, king of France. Forens Sci Int: Genetics 2011, 5, 459-463
- Lucotte G: A rare variant of the mtDNA HVS1 sequence in the hairs of NapolÃ©onâ€™s family, Invest Genet 2010, 1, 7-10
- Lucotte G, Thomasset T, Hrechdakian P: Haplogroup of the Y chromosome of NapolÃ©on the first. J Mol Biol Res 2011, 1, 12-19
- Karafet TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL, Hammer MF: New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree. Genome Res, 2008, 18, 830-838
- Athey W: Haplogroup prediction from Y-STR values using a Bayesian allele frequency approach. J Genet Geneal 2006, 2, 34-39
- Redd A, Agellon AlB, Kearney VA, Contreras VA, Karafet T, Park H, de Knijff P, Butler JM, Hammer MF: Forensic value of 14 novel STRs on the human Y chromosome. Forens Sci Int: Genetics 2002, 130, 97-111
- Butler JM, Decker AE, Vallone PM, Kline MC: Allele frequencies for 27 Y-STR loci with U.S. Caucasian, Africans Americans and Hispanic samples. Forens Sci Int 2006, 156: 250-260
- Dâ€™Amato ME, Ehrenreich L, Cloete K, Benjeddou M, Davison S: Characterisation of the highly discriminatory loci DYS449, DYS481, DYS518, DYS612, DYS626, DYS664 and DYS710. Forens Sci Int: Genetics 2012, 4: 104-110
- Burgarella C, NavascuÃ©s M: Mutation rate estimates for 110 Y-chromosome STRs combining population and father-son pair data. Eur J Hum Genet 2011 19, 70-75
- Hanson EK, Ballantyne J: Comprehensive annotated STR physical map of the human Y chromosome: forensic implications. Legal Medecine 2006, 8, 110-120
- Unpublished CEPH datas (CEPH 1333-01). A study based on 32841 DYS454 alleles
- Norved K (personal communication). The allele range and mode reported in Table 3 are based on the distribution of 70 subjects belonging to the I1 haplogroup
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