Preclinical Atherosclerosis, Metabolic Syndrome and Risk of Cardiovascular Events

Preclinical Atherosclerosis, Metabolic Syndrome and Risk of Cardiovascular Events

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Author(s)

Author(s): Annalisa Graceffa, Salvatore Novo, Matteo Cameli, Marco Matteo Ciccone, Maria Maiello, Pietro A Modesti, Maria Lorenza Muiesan, Ida Muratori, Giuseppina Novo, Pasquale Palmiero, Angelica Peritore, Pier Sergio Saba, Pietro Scicchitano, Rosalinda Trovato, Roberto Pedrinelli

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399 1053 33-42 Volume 3 - Jul 2014

Abstract

The CVD represent nowadays the first cause of mortality and disability in western country. But atherosclerosis disease is a gradually process that develops over decades, giving the time to carry out prevention and intervention strategy. Great attention should be made on the analysis of RF and on their correction, especially when they are clustered in a manner that enhances them. For this reason, it’s important to prevent the development of MetS abnormalities (for example with daily physical activity and Mediterranean diet) and to detect it early so as start pharmacological treatment of modifiable risk factors. Moreover, in order to address the therapeutic efforts to the subjects that can receive greater benefit, it is important to have tool to identify subjects affected but non symptomatic yet. For this purpose, non-invasive techniques capable of evaluating arterial wall and endothelial function should enter in routinely evaluation of cardiovascular risk. In particular, according to ESC guidelines (1), carotid ultrasonography, brachial-ankle index measurement and computed tomography for coronary calcium assessment should be taken in mind for further risk stratification of asymptomatic adults at moderate risk. The detection of subclinical lesions indicates the need of a more aggressive management of risk factors, possibly with the help of drug treatment.

References

  1. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M, Albus C, Benlian P, Boysen G, Cifkova R, et al.: European Association for Cardiovascular Prevention & Rehabilitation (EACPR); ESC Committee for Practice Guidelines (CPG). European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J. 2012;33(13):1635-701
  2. Johnson KM, Dowe DA, Brink JA. Traditional clinical risk assessment tools do not accurately predict coronary atherosclerotic plaque burden: a CT angiography study. AJR Am J Roentgenol. 2009;192(1):235-43
  3. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003; 108:1664 –72
  4. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM,Smith SC Jr;. International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120(16):1640-5
  5. Kassi E, Pervanidou P, Kaltsas G, Chrousos G. Metabolic syndrome: definitions and controversies. BMC Med. 2011; 9:48
  6. McNeill AM, Rosamond WD, Girman CJ, Heiss G, Golden SH, Duncan BB, East HE, Ballantyne C. Prevalence of coronary heart disease and carotid arterial thickening in patients with the metabolic syndrome (The ARIC Study). Am J Cardiol. 2004; 94(10):1249-54
  7. Koskinen J, Kähönen M, Viikari JS, Taittonen L, Laitinen T, Rönnemaa T, Lehtimäki T, Hutri-Kähönen N,Pietikäinen M, Jokinen E, et al. Conventional cardiovascular risk factors and metabolic syndrome in predicting carotid intima-media thickness progression in young adults: the cardiovascular risk in young Finns study. Circulation. 2009; 120 (3):229-36
  8. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Bonadonna RC, Muggeo M; Bruneck study. Carotid atherosclerosis and coronary heart disease in the metabolic syndrome: prospective data from the Bruneck study. Diabetes Care. 2003; 26(4):1251-7
  9. Herder M, Arntzen KA, Johnsen SH, Mathiesen EB. The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study. Cardiovasc Diabetol. 2012; 11:77
  10. Novo S, Peritore A, Trovato RL, Guarneri FP, Di Lisi D, Muratori I, Novo G. Preclinical atherosclerosis and metabolic syndrome increase cardio- and cerebrovascular events rate: a 20-year follow up. Cardiovasc Diabetol. 2013; 12(1):155
  11. Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome— a new worldwide definition. Lancet. 2005; 366(9491):1059-62
  12. J. K. Olijhoek, Y. Van Der Graaf, J.-D. Banga, A. Algra, T. J. Rabelink, and F. L. J. Visseren, SMART Study Group. The Metabolic syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic aneurysm. Eur Heart J. 2004; 25(4):342-8
  13. Mente A, Yusuf S, Islam S, McQueen MJ, Tanomsup S, Onen CL, Rangarajan S, Gerstein HC, Anand SS, INTERHEART Investigators: Metabolic syndrome and risk of acute myocardial infarction a case control study of 26,903 subjects from 52 countries. J Am Coll Cardiol 2010, 55:2390-98
  14. Bruno G, Merletti F, Biggeri A, Bargero G, Ferrero S, Runzo C, Prina Cerai S, Pagano G, Cavallo-Perin P, Casale Monferrato Study: Metabolic syndrome as a predictor of all-cause and cardiovascular mortality in type 2 diabetes: the Casale Monferrato Study. Diabetes Care 2004, 27:2689-94
  15. Novo S, Peritore A, Guarneri FP, Corrado E, Macaione F, Evola S, Novo G. Metabolic syndrome (MetS) predicts cardio and cerebrovascular events in a twenty years follow-up. A prospective study. Atherosclerosis. 2012; 223(2):468-72
  16. Grundy S. M. Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. J Am Coll Cardiol. 2006; 47(6):1093-100
  17. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999; 340(1):14-22
  18. Lane HA, Smith JC, Davies JS. Noninvasive assessment of preclinical atherosclerosis. Vasc Health Risk Manag. 2006;2 (1):19-30
  19. Daniel H. O’Leary, Michiel L. Bots. Imaging of atherosclerosis: carotid intima–media thickness. Eur Heart J. 2010;31 (14):1682-9
  20. Preclinical Atherosclerosis, Global Cardiovascular Risk and Cardiovascular Events. Editor Salvatore Novo. Co-Editor(s): Jawed Fareed, Evi Kalodiki and Jeanine M. Walenga.Bentham Sciences Publisher, Monographies 2012
  21. Novo S, Carità P, Corrado E, Muratori I, Pernice C, Tantillo R, Novo G. Preclinical carotid atherosclerosis enhances the global cardiovascular risk and increases the rate of cerebro- and cardiovascular events in a five-year follow-up. Atherosclerosis. 2010; 211(1):287-90
  22. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007;115 (4):459-67
  23. Corrado E, Rizzo M, Muratori I, Coppola G, Novo S. Older age and markers of inflammation are strong predictors of clinical events in women with asymptomatic carotid lesions. Menopause. 2008;15(2):240-7
  24. Rizzo M, Corrado E, Coppola G, Muratori I, Novo G, Novo S. Prediction of cardio- and cerebro-vascular events in patients with subclinical carotid atherosclerosis and low HDL-cholesterol. Atherosclerosis. 2008; 200 (2):389-95
  25. Novo G, Corrado E, Muratori I, Tantillo R, Bellia A, Galluzzo A, Vitale G, Novo S. Markers of inflammation and prevalence of vascular disease in patients with metabolic syndrome. Int Angiol. 2007; 26(4):312-7
  26. Novo S, Visconti CL, Amoroso GR, Corrado E, Fazio G, Muratori I, Tantillo R, Lunetta M, D'Angelo L, Novo G. Asymptomatic carotid lesions add to cardiovascular risk prediction. Eur J Cardiovasc Prev Rehabil. 2010; 17(5):514-8
  27. Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006; 37(1):87-92
  28. Romano G, Corrado E, Muratori I, Novo G, Andolina G, Cospite V, Evola S, Ciaramitaro GF, Di Vincenzo A, Farinella M, Rotolo A, Assennato P, Hoffmann E, Novo S. Carotid and peripheral atherosclerosis in patients who underwent primary percutaneous coronary intervention and outcome associated with multifocal atherosclerosis. Int Angiol. 2006; 25(4):389-94
  29. Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, Azen SP. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998; 128(4):262-9
  30. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study. N Engl J Med 1999; 340:14–22
  31. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146:483–94
  32. Plantinga Y, Dogan S, Grobbee DE, Bots ML. Carotid intima-media thickness measurement in cardiovascular screening programmes. Eur J Cardiovasc Prev Rehabil 2009; 16:639–44
  33. Nambi V, Chambless L, Folsom AR, He M, Hu Y, Mosley T, Volcik K, Boerwinkle E, Ballantyne CM. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: The ARIC (Atherosclerosis Risk in Communities). Study J Am Coll Cardiol 2010; 55: 1600–07
  34. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013; 34(28):2159-219
  35. Detrano RC, Anderson M, Nelson J, Wong ND, Carr JJ, McNitt-Gray M, Bild DE. Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility—MESA study. Radiology. 2005; 236(2): 477-84
  36. Vogt MT, Cauley JA, Newman AB, Kuller LH, Hulley SB. Decreased ankle/arm blood pressure index and mortality in elderly women. JAMA 1993; 270:465–469
  37. Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA 2008; 300:197–208
  38. Dormandy A, Creager MA. Ankle: arm blood pressure index as a predictor of atherothrombotic events. Evidence from CAPRIE. Cerebrovasc Dis 1999; 9 (Suppl 1): 1-128 (abstract 4)
  39. Hirsch AT, Criqui MH, Treat-Jacobson D, Regensteiner JG, Creager MA, Olin JW, Krook SH, Hunninghake DB, Comerota AJ et al. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA 2001; 286: 1317-24
  40. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG and TASC II Working Group; Bell K, Caporusso J, Durand-Zaleski I, et al. Inter-society consensus for the management of peripheral arterial disease (TASC II). J. Eur J Vasc Endovasc Surg. 2007; 33 (Suppl 1): S1-75
  41. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340:1111–15
  42. M. Charakida Masi S, Lüscher TF, Kastelein JJ, Deanfield JE. Assessment of atherosclerosis: the role of flow-mediated dilatation. Eur Heart J. 2010; 31(23):2854-61
  43. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, et al. (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002; 39 (2):257-65
  44. Juonala M, Viikari JS, Laitinen T, Marniemi J, Helenius H, Ronnemaa T, Raitakari OT. Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study. Circulation 2004; 110:2918–23
  45. Frick M, Schwarzacher SP, Alber HF, Rinner A, Ulmer H, Pachinger O, Weidinger F. Morphologic rather than functional or mechanical sonographic parameters of the brachial artery are related to angiographically evident coronary atherosclerosis. J Am Coll Cardiol. 2002; 40 (10):1825-30
  46. Witte DR, van der Graaf Y, Grobbee DE, Bots ML; SMART Study Group. Measurement of flow-mediated dilatation of the brachial artery is affected by local elastic vessel wall properties in high-risk patients. Atherosclerosis. 2005; 182 (2):323-30
  47. Teragawa H, Ueda K, Matsuda K, Kimura M, Higashi Y, Oshima T, Yoshizumi M, Chayama K. Relationship between endothelial function in the coronary and brachial arteries. Clin Cardiol. 2005; 28 (10):460-6
  48. Yeboah J, Folsom AR, Burke GL, Johnson C, Polak JF, Post W, Lima JA, Crouse JR, Herrington DM. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the Multi-Ethnic Study of Atherosclerosis. Circulation. 2009; 120:502–09
  49. Yeboah J, Crouse JR, Hsu F-C, Burke GL, Herrington DM. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation. 2007; 115: 2390–97
  50. Green DJ, Jones H, Thijssen D, Cable NT, Atkinson G. Flow-Mediated Dilation and Cardiovascular Event Prediction: Does Nitric Oxide Matter? Hypertension. 2011; 57:363-69
  51. Witte DR, Westerink J, de Koning EJ, van der Graaf Y, Grobbee DE, Bots ML. Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations? J Am Coll Cardiol. 2005; 45:1987–93
  52. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr., Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15:827–832
  53. Burke AP, Kolodgie FD, Farb A, Weber D, Virmani R. Morphological predictors of arterial remodeling in coronary atherosclerosis. Circulation 2002; 105: 297–303
  54. Vliegenthart R, Oudkerk M, Song B, van der Kuip DA, Hofman A, Witteman JC. Coronary calcification detected by electron-beam computed tomography and myocardial infarction. The Rotterdam Coronary Calcification Study. Eur Heart J 2002;23:1596–603
  55. Folsom AR, Kronmal RA, Detrano RC, O’Leary DH, Bild DE, Bluemke DA, Budoff MJ, Liu K, Shea S, Szklo M, et al. Coronary artery calcification compared with carotid intima-media thickness in prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med 2008; 168:1333–39
  56. Task Force Members, Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013; 34(38):2949-3003
  57. Budoff MJ, Dowe D, Jollis JG, Gitter M, Sutherland J, Halamert E, Scherer M, Bellinger R, Martin A, Benton R, et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 2008; 52:1724–32
  58. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27:2588–605
  59. Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T, Filipovsky J, Huybrechts S, Mattace-Raso FU, Protogerou AD, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 2012; 30:445–48
  60. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, SchalekampMA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 2006; 113:657–63

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