PERK Signaling Pathway Involved in Lactic Acid Induced Astrocyte Damage

PERK Signaling Pathway Involved in Lactic Acid Induced Astrocyte Damage

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Author(s): Jian-Zhong Zhang, Li Jing, Ru Yan, Xiang-Mei Cao, Qing-Ping He, P. Andy Li

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388 1080 29-34 Volume 3 - Oct 2014


Diabetes is an important modifiable risk factor for cerebral ischemic stroke. It increases infraction area and restrains astrocyte activation. Meanwhile, hyperglycemia increase lactic acid and decreases pH. Lactic acid may partially be accountable for the detrimental effects of diabetes on ischemic stroke. The objective of this study was to investigate the effect of lactic acid on astrocyte viability and to explore the potential mechanisms that lactic acid enhances astrocyte cell death. Astrocytes were challenged by various concentrations of lactic acid (0, 2.5, 5,10 and 15 mM). Cell viability and PERK pathway were examined. The results showed that lactic acid resulted in astrocyte death (p<0.05) and activation of GRP78 and PERK (p<0.05). It is concluded that lactate acidosis causes stress to the endoplasmic reticulum.


Acidosis, Astrocyte, Lactic acid, GRP78, PERK


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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
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