Emblica Officinalis Protects Against Sodium Arsenite Induced Hepatotoxicity & Nephrotoxicity In Rats

Emblica Officinalis Protects Against Sodium Arsenite Induced Hepatotoxicity & Nephrotoxicity In Rats

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Author(s)

Author(s): Arun Kumar, Raj Bala, Farida Bano, Ranjit Kumar, Mohammad Ali

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DOI: 10.18483/ijSci.652 363 1094 47-55 Volume 4 - Mar 2015

Abstract

Arsenic in the present times has caused lots of health hazards to humans. In developing countries like Bangladesh and India the high prevalence of contamination, the isolation and poverty of the rural population, and the high cost and complexity of arsenic removal systems have imposed a programmatic and policy challenge on an unprecedented scale. Although in India, Arsenic poisoning in ground water in Gangetic belt especially the districts adjoining the river Ganges right from Eastern Uttar Pradesh, Bihar to West Bengal are the major problem of concern as due to which major health related problems are arising. To combat the present problem, a pre-clinical study was done on Charles foster rats. They were treated with Sodium arsenite for 8 weeks to make arsenic model and upon these arsenic pretreated rats Emblica officinalis was administered for 4 weeks to study the antidote effects of this plant. The plant not only eliminated the effects of arsenic but also reversed the normal physiological activity in the animal by normalising the activity of liver and kidney. The present study concludes that this novel plant possesses hepato-protective as well as nephron-protective activity against arsenic induced toxicity.

Keywords

Sodium Arsenite, Emblica Officinalis, Antidote Effect, Rats

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