Acetone and 6-Methyl-5-Hepten-2-One in Skin Gas Increase during Handgrip Exercise

Acetone and 6-Methyl-5-Hepten-2-One in Skin Gas Increase during Handgrip Exercise

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Author(s)

Author(s): Tetsuo Ohkuwa, Toshiaki Funada, Katsumi Hirai, HiroshiIto, Takao Tsuda

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DOI: 10.18483/ijSci.790 372 860 37-44 Volume 4 - Aug 2015

Abstract

The present study investigated the effect of dynamic handgrip exercise on acetone, 6-methyl-5-hepten-2-one, acetaldehyde, and hexanal levels in skin gas. Participants in this experiment consisted of six healthy males. Skin gas was collected two times. First, skin gas during rest (i.e., before the exercise) was collected for 3 min into the sampling bag. Next, the exercise using a handgrip exercise instrument was performed. The hand performed a dynamic handgrip exercise for 3 min inside the sampling bag, exerting one 30 kg contraction per second. The blood flow at the end of the handgrip exercise increased by about 1.4 times that before exercise and then decreased to basal levels immediately thereafter. Acetone and 6-methyl-5-hepten-2-one concentrations after exercise significantly increased relative to basal levels. Significant differences were not observed in acetaldehyde and hexanal concentrations between at rest and after handgrip exercise. The amount of acetone and 6-methyl-5-hepten-2-one released from forearm skin increased during dynamic handgrip exercise. Acetaldehyde and hexanal levels did not increase during exercise compared with levels at rest.

Keywords

6-Methyl-5-Hepten-2-One, Acetone, Acetaldehyde, Hexanal, Human Skin Gas

References

  1. Balasse EO, Ferry F. Ketone body production and disposal: effects of fasting, diabetes, and exercise. Diabetes Metab Rev 1989; 5: 247-270.
  2. Clemens DL, Forman A, Jerrells TR, Sorrell MF, Tuma D. Relationship between and cell survival in ethanol-metabolizing hepatoma calls. Hepatology 2002; 35: 1196-1204.
  3. Crabb DW, Matsumoto M, Chang D, You M, Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genisis of alcohol-related pathology. 2004; 63: 49-63.
  4. de Lacy Costello B, Amman A, Al-Kateb H, Flynn C, Filipiak W, Ratcliffe NMJ. A review of the volatiles from the healthy human body. J Breath Res 2014, 8, No.014001.
  5. Frankel EN. Lipid oxidation. Prog Lipid Res 2002; 19: 1-22.
  6. Filipiak W, Sponring A, Baur MM, Filipiak A, Ager C, Wiesenhofer H, Nagl M, Troppmair J, Amann A. Molecular analysis of volatile metabolites released specifically by staphylococcus aureus and pseudomonas aeruginosa. BMC Microbial 2012; 12: 113-129.
  7. Fujisaki M, Endo Y, Fujimoto K. Retardation of volatile aldehyde formation in the exhaust of frying oil heating under low oxygen atmospheres JAOCS 2002; 79: 909-914.
  8. Fruekilde P, Hjorth J, Jensen NR, Kotzias D, Larsen B. Ozonolysis at vegetation surfaces: a source of acetone, 4-oxopentanal, 6-methyl-5-hepten-2-one, and geranyl aceton in the troposphere. Atmospheric Environment 1998; 32: 1983-1902.
  9. Holownia A, Ledig M, Braszko JJ, Menez JF. Acetaldehyde cytotoxicity in cultured rat astrocytes. Brain Res 1999; 833: 202-208.
  10. Laffel L, Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metb Res Rev 1999; 15: 412-426.
  11. Liu GCK, Ahrens EH, Schreibman PH, Crouse JR. Mesurement of squalene in human tissues and plasma: validation and application. J Lipid Res 1976; 17: 38-45
  12. MacDonald M, Naylor H, Tschakovsky ME, Hughson R. Peripheral circulatory factors limit rate of increase in muscle O2 uptake at onset of heavy exercise. J Appl Physiol 2001; 90: 83-89.
  13. Mochalski Pa, Unterkofler K, Spanel P, Smith D, Amann A. Product ion distributions for the reactions of NO+ with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument. Int J Mas Spectrometry 2014; 363: 23-31.
  14. Mochalski Pb, King J, Unterkofler K, Hinterhuber H, Amann A. Emission rates of selected volatile organic compounds from skin of healthy volunteers. J Chromatogr B 2014; 959: 62-70
  15. Mochalski Pc, Unterkofler K, Hinterhuber H, Ammann A. Monitoring of selected skin-bone volatile markers of entrapped human by selective reagent ionization time of flight mass spectrometry in NO+ mode. Anal Chem 2014; 86: 3915-3923. Valacchi 2010
  16. Mori K, Funada T, Kikuchi M, Ohkuwa T, Itoh H, Yamazaki Y, Tsuda T. Influence of dynamic hand-grip exercise on acetone in gas emanating from human skin. Red Rep 2008; 13: 139-141.
  17. Owen OE, Trapp VE, Skutches et al. Acetone metabolism during diabetic ketoacidosis. Diabetes 1982; 31: 242-248.
  18. Petrick L, Dubowski Y. Heterogeneous oxidation of squalene film by ozon under various indoor conditions. Indoor Air 2009; 19: 381-391.
  19. Sasaki H, Ishikawa S, Ueda H, Kimura Y. YoshikawaT Naito Y (eds): Gas Biology Research in Clinical Paractice. Base, Karger, 2011, pp119-124.2011
  20. Schwarz K, Pizzini A, Arendack’a B, Zerlauth K, Filipiak W, Schmid A, Dzien A, Neuner S, Lechleitner M, Scholl S, Miekisch W, Schubert J, Unterkofler K, Witkovsk V, Gast G, Amann A. Breath acetone: aspects of normal physiology related to age and gender as determined in a PTR-MS study. J Breath Res. 2009; 3: 027003.
  21. Smith D, Wang T, Spanel P. Kinetics and isotope patterns of ethanol and acetaldehyde emission from yeast fermentations of glucose and glucose-6, 6-d2 during selected ion flow tube mass spectromatory : a case study. 2002; 16: 69-76.
  22. Smith D, Wang T, Sule-Suso J, Spanel P, Haj AE. Quantification of acetaldehyde release by lung cancer cells in vitro using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom 2003; 17: 845-850.
  23. Smith KR, Thiboutot DM, Sebaceous gland lipid: friend or foe? J Lipid Res 2008; 49: 271-281.
  24. Turner C, Spanel P, Swimth D. A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry. Rapid Commun Mass Spectrom 2006; 20: 61-68.
  25. Turner C, Parekh B, Walton C, Spanel P, Smith D, Evans M. An explotratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom 2008; 22: 526-532.
  26. Wahren J, Hagenfeldt L, Fehlig P. Splancnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus. J Clin Invest 1975; 55: 1303-1314.
  27. Wisthaler A, Weschler CJ. Reaction of ozon with human lipid: sources of carbonyls, dicarbonyls, and hydroxycarbonyls in indoor air. PNAS 2010; 107: 6568-6575.
  28. Yamai K, Ohkuwa T, Itoh H, Yamazaki Y, Tsu T. Influence of ccycle exercise on acetone in expired air and skin gas. Red Rep 2009; 14 (6): 285-289.

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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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