Age-Dependent Effects C57BL/6 Genetic Mutations under Mice Models of Parkinson’s Disease on Motor Ability

Age-Dependent Effects C57BL/6 Genetic Mutations under Mice Models of Parkinson’s Disease on Motor Ability

Author(s)

Lin Hou, Zhixiang Chen, Shengmin Zhao, Yaoyue Wei

Download Full PDF DOI: 10.18483/ijSci.855 Downloads: 171 Views: 520 Pages: 9-11

Volume 4 - October 2015 (10)

Abstract

As literature reported, C57BL/6 A53T mutant human alpha-synuclein under the mice is one successful model related to Parkinson’s disease(PD). In previous studies, over-accumulation of alpha-synuclein which lead to lewy body, were revealed to cause impairment on motor ability in Parkinson’s disease mouse model. Nevertheless, in the open filed test and the rota-rod test, hyperactivity and motor ability improvements at 12 months old was found in our study.

Keywords

Parkinson’s Disease; Motor Ability; Hyperactivity; Genetic Mutation

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Cite this Article:

International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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