Effects of Intensive Exercise Training Combined with Prophylactic Antidepressant Treatment on Motor Function and Depression in Patients with Stroke

Effects of Intensive Exercise Training Combined with Prophylactic Antidepressant Treatment on Motor Function and Depression in Patients with Stroke

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Author(s)

Author(s): Fang Pin-Yeh, Wang Qiang

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DOI: 10.18483/ijSci.1215 149 572 81-89 Volume 6 - Mar 2017

Abstract

Objective:To observe the effects of intensive exercise training combined with prophylactic antidepressant treatment on motor function and depression in patients with stroke. Methods:45 patients with stroke (not diagnosed as post stroke depression,PSD) were randomly divided into three groups by random number table: the simple treatment group, the intensive exercise training group, and the intensive exercise training + prophylactic antidepressant treatment group, each for 15 cases. The patients of 3 groups were given routine stroke drug therapy and rehabilitation training. On the basis of this, the intensive exercise training group increased motor function training once a day. In addition to increasing motor function training once a day, the intensive exercise training + prophylactic antidepressant treatment group was given further prevention of antidepressant medication. The modified Barthel index scale (MBI), Fugl-Meyer Assessment (FMA), Self-rating depression scale (SDS) were used to evaluate the motor function and depression of the patients in the 2rd and 4th week after treatment. Results:Before treatment, there was no significant difference among the three groups in Barhtel, FMA and depression index. After treatment, the Barthel index and FMA score of the treatment group and the intensive exercise training + prophylactic antidepressant treatment group were significantly different from those of simple treatment group. The ADL and FMA scores of the 2 groups were higher than those of the simple treatment group(P <0.05). Compared with the intensive exercise training group, the Barthel index and FMA score showed no significant advantage in the intensive exercise training + prophylactic antidepressant treatment group. The SDS scores of the three groups were not statistically significant between the groups before and after treatment (in the group). Conclusion:Intensive exercise training therapy can effectively improve the overall prognosis of patients with stroke and improve the effects of clinical rehabilitation. There was no statistically significant difference in the recovery of motor function and the incidence of PSD in patients receiving prophylactic antidepressant treatment compared with patients who did not receive prophylactic antidepressant treatment. Considering that there is no PSD in the patients before and after the experiment, and the observation time is short, it is still not possible to draw the conclusion that prophylactic antidepressant treatment is ineffective.

Keywords

PSD, intensive exercise training, modified Barthel index scale (MBI), Fugl-Meyer Assessment scale (FMA), depression, prophylactic antidepressant treatment

References

  1. Brown C,Hasson H ,Thyselius V,et al . Post -stroke depression and functional independence a conundrum . Act a Neurologica Scandinavica,2012; 126(1):45-51.
  2. Xie Jiaxin,Family rehabilitation nursing of stroke patients with hemiplegia’ Chinese Rehabilitation Theory and Practice,2002,8(2):116-7
  3. Hu Xiaohua,Dong Yan,Jing Shan, et al. Clinical observation of hyperbaric oxygen combined with fluoxetine in the treatment of post stroke depression. Chinese Journal of physical medicine and rehabilitation,2014; 36(6):455-457.
  4. Mukherjee D,Patil C G. Epidemiology and the Global Burden of Stroke [J].World Neurosurg,2011.76(6):S85~S90
  5. Murray C J, Lopez A D.Mortality by cause for eight regions of the world:Global Burden of Disease Study[J].Lancet,1997.349(9061):1269~1276
  6. Deng Jingyuan,Liu Yamin,Lv Yali, et al. Meta-analysis of the relationship between the brain lesion and post stroke depression in patients with acute stroke. Journal of Jilin University(Medical Edition),2012;38(3):532-536.
  7. Zhao Xianwei, Tang Xinhui, Gao Ruilong, et al. Clinical study of early rehabilitation therapy on post stroke depression.Chinese Journal of physical medicine and rehabilitation. 2004,26:306-307.
  8. Liu Yi, Liao Shipeng, Ji Qiuming, et al. A comparative study of antidepressant drugs combined with psychotherapy in the treatment of post stroke depression. International psychiatry research,2015 ; 42(2):53-56.
  9. Zhang Xiuling. The effect of post stroke depression on the recovery of neurological function. Chinese Journal of practical neurological diseases,2012; 15(1): 24-25
  10. Shi Lina, Zhu Qingyu, Rong Genman. Incidence and clinical features of post stroke depression. Chinese and foreign medical research,2012; 10(13):142-143.
  11. Liu Xianling. The analysis of Pa Rossi Dean and imipramine on the curative effect of improved recovery of post-stroke depression and neurological function. Chinese Journal of practical neurological diseases,2012 ; 15(21):83-84.
  12. Wang Huiting, Wen Qingxiu, Chen Xiqu, et al. Analysis of depression and its influencing factors in elderly patients with stroke [J]. Nursing Journal 2016, 23(23)Astron M, Adolfsson R, Asplund K. Major depression in stroke patients.A 3-year long itudinal study.Stroke, 1 9 9 3, 2 4 (7):976 - 982.
  13. Kwakkel G. Impact of intensity of practice after stroke: issue for consideration [J]. DisabilRehabil. 2006, 28: 823 - 830
  14. Yang Jian, Qiao Lei, Zhu Lei, et al. Effects of individual active rehabilitation on motor function and 13 activities of daily living in patients with hemiplegia after stroke [J].Chinese Journal of rehabilitation medicine,2007,22(6):514-517.DOI:10.3969/j.issn.1001—1242.2007.06.009.
  15. Li Ming, Wang Qiang, Ma Jian, et al. Effect of intensive training on lower limb motor function and depression in patients with post stroke depression [J]. Chinese Journal of physical medicine and rehabilitation, 2016, 38(4):283-286.
  16. Varambally S,Naveen GH,Rao MG,et a1.Low senlmbrain derivedneurotrophic factor innon-suicidalout—patients with depression:relation to depression scores[J].Indian J Psychiatry,2013,55(3):$397.399.DOI:10.4103/0019—5545.116311.
  17. HeymanE,Gamelin FX,Goekint M,et a1.Intense exercise increases circulating endocannabinoid and BDNF levels in humans—possibleimplications for reward and depression[J].Psyehoneuroendoerinology,2012,37(6):844—851.DOI:10.1016/j.psyneuen.2011.09.017.
  18. Pulsinelli WA. The therapeutic window in ischemic brain injury [J]. Curr Opin Neurol, 1995, 8: 3-5.

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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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