A New Inhibitor of γ-aminobutric Acid Aminotransferase from Streptomyces sp. ZZ035 Isolated from a Folk Medicinal Soil in China

A New Inhibitor of γ-aminobutric Acid Aminotransferase from Streptomyces sp. ZZ035 Isolated from a Folk Medicinal Soil in China

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Author(s): Xuejie Xu, Xuejiao Wu, Ganjun Yuan, Qiwang Zhong, Li Xu

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DOI: 10.18483/ijSci.1225 226 667 100-105 Volume 6 - Mar 2017


Strain ZZ035 was isolated from a folk medicinal soil in China. Polyphasic taxonomy procedure indicated that this strain belonged to the genus Streptomyces and was closest to S. cinnamonensis with high similarities (99.2%) of 16S rDNA sequence. 1 was isolated from the broth of this strain and identified as 5-amonimethyl-2-iminoimidazolidine-4-carboxylic acid. Its chemical structure was established by its spectroscopic data, and 1H and 13C signals were assigned by its 1H, 13C, Dept and HSQC spectra. Considering that 1 was a γ-aminobutric acid (GABA) derivative, its inhibitory activity against GABA-aminotransferase (GABA-AT) was assayed, and the result showed that 1 can inhibit GABA-AT activity with the 50% inhibitory concentration of approximately 60 μM. As 1 was a 2,3-disubstituted GABA derivative not published before, the approximate GABA-AT inhibitory activity of 1 compared to positive control vigabatrin showed that 1 were worthy of further research and developing.


Actinomycete, Streptomyces sp. ZZ035, γ-Aminobutric acid derivative, γ-Aminobutric acid-aminotransferase, Inhibitor


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