The Influence of Perineural Invation on the Prognosis of Patients with Gastric Cancer after Radical Operation _A Retrospective Study

The Influence of Perineural Invation on the Prognosis of Patients with Gastric Cancer after Radical Operation _A Retrospective Study

Loading document ...
Loading page ...


Author(s): Houxin Zhu, Lin Sun, Tuo Shi

Download Full PDF Read Complete Article

DOI: 10.18483/ijSci.1827 46 159 30-34 Volume 7 - Nov 2018


Objective to investigate the influence of perineural invation (PNI) on the prognosis of patients with gastric cancer after radical resection. Method: we collected 278 patients in Affiliated Hospital of Qingdao University with gastric cancer after radical operation and to analysis. The specimens of gastric cancer were stained with hematoxylin and eosin (HE), when the tumor cells were infiltrated the membrane or the nerve bundles, it would be defined as PNI positive. To analyzed the relationship between PNI and other clinic-pathological features and the influence of prognosis. Results: The 5-year overall survival of the patients with PNI were lower than those of the patients with negative perineural infiltration (26.45% vs 43.72%, P<0.05).Multivariate analysis showed that PNI was an independent factor affecting the prognosis of the patients (p = 0.023, HR = 0.182, 95CI: 0.042 - 0.793). The rate of PNI was 30.57% (85/278). PNI positive was related to TNM stage, tumor differentiation, vascular and lymphatic invasion and Lauren classification (p < 0.05)., but the size of tumor, the location of tumor and Borrmann classification were not significant (p>0.05). Conclusion: patients with PNI positive with lower rate of survival. PNI positive is related to the progression of gastric cancer.


Gastric Cancer, Perineural Infiltration, Radical Operation, Prognosis


  1. Sakuramoto, S., et al., Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med, 2007. 357(18): p. 1810-20.
  2. Strong, V.E., et al., Comparison of gastric cancer survival following R0 resection in the United States and Korea using an internationally validated nomogram. Ann Surg, 2010. 251(4): p. 640-6.
  3. Yazici, O., et al., The effect of the gastrectomy on survival in patients with metastatic gastric cancer: a study of ASMO. Future Oncol, 2016. 12(3): p. 343-54.
  4. Nakajima, T., Gastric cancer treatment guidelines in Japan. Gastric Cancer, 2002. 5(1): p. 1-5.
  5. Huang, J.Y., et al., The prognostic impact of occult lymph node metastasis in node-negative gastric cancer: a systematic review and meta-analysis. Ann Surg Oncol, 2013. 20(12): p. 3927-34.
  6. Zhang, X.F., et al., Surgical treatment and prognosis of gastric cancer in 2,613 patients. World J Gastroenterol, 2004. 10(23): p. 3405-8.
  7. An, J.Y., et al., Pathologic and oncologic outcomes in locally advanced gastric cancer with neoadjuvant chemotherapy or chemoradiotherapy. Yonsei Med J, 2013. 54(4): p. 888-94.
  8. Li, P., et al., Vascular invasion as an independent predictor of poor prognosis in nonmetastatic gastric cancer after curative resection. Int J Clin Exp Pathol, 2015. 8(4): p. 3910-8.

Cite this Article:

International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

Search Articles

Issue June 2023

Volume 12, June 2023

Table of Contents

World-wide Delivery is FREE

Share this Issue with Friends:

Submit your Paper