Analysis of Myelin Using the Resonant Recognition Model

Analysis of Myelin Using the Resonant Recognition Model

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Author(s): Irena Cosic, Drasko Cosic

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DOI: 10.18483/ijSci.2743 7 14 10-14 Volume 13 - Jan 2024


Both Multiple Sclerosis (MS) and possibly Alzheimer Disease (AD) are caused by damage of myelin sheath, which is an insulating layer of lipids and proteins surrounding nerves. By using the Resonant Recognition Model (RRM), which can identify critical parameters for function/interaction of biological molecules, we have analysed here all the participants in the formation and stability of myelin with the aim to understand its complex function. Interestingly, we have identified here that all participants in myelin formation and stability do have only one common RRM frequency, indicating that this RRM frequency is critical for myelin formation and stability. With such identified RRM characteristic frequency, the next step would be to design de novo bioactive peptides, which might be able to facilitate repair of damaged myelin and could lead to new possible treatment of MS and AD.


Myelin, Multiple Sclerosis, Alzheimer Disease, Resonant Recognition Model


  1. Compston A, Coles A (October 2008). "Multiple sclerosis". Lancet. 372 (9648): 1502–1517. doi:10.1016/S0140-6736(08)61620-7.
  2. Papuć E, Rejdak K. The role of myelin damage in Alzheimer's disease pathology. Arch Med Sci. 2018 Aug 28;16(2):345-351. doi: 10.5114/aoms.2018.76863.
  3. Bean, Bruce P. (June 2007). "The action potential in mammalian central neurons". Nature Reviews Neuroscience, 8 (6): 451–465, doi:10.1038/nrn2148.
  4. Steinman L: Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell, 1996; 85(3), 299–302, doi: 10.1016/S0092-8674(00)81107-1.
  5. Mallucci G, Peruzzotti-Jametti L, Bernstock JD, Pluchino S: The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis. Progress in Neurobiology, 2015; 127–128, 1–22, doi: 10.1016/j.pneurobio.2015.02.003.
  6. Greer JM, Lees MB: Myelin proteolipid protein--the first 50 years. The International Journal of Biochemistry & Cell Biology, 2002; 34(3), 211–215, doi: 10.1016/S1357-2725(01)00136-4.
  7. Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA: High cholesterol level is essential for myelin membrane growth. Nature Neuroscience, 2005; 8(4), 468–470, doi: 10.1038/nn1426.
  8. Cosic I: Macromolecular Bioactivity: Is it Resonant Interaction between Macromolecules? -Theory and Applications. IEEE Trans on Biomedical Engineering, 1994; 41, 1101-1114.
  9. Cosic I: Virtual spectroscopy for fun and profit. Biotechnology, 1995; 13, 236-238.
  10. Cosic I: The Resonant Recognition Model of Macromolecular Bioactivity: Theory and Applications. Basel: Birkhauser Verlag, 1997.
  11. Cosic I: Resonant Recognition Model of Protein Protein and Protein DNA Recognition in Bioinstrumentation and Biosensors. ed by Wise D. Marcel Dekker Inc., New York, 1990; 475-510.
  12. Cosic I, Cosic D: Macromolecular Resonances. In: Bandyopadhyay A., Ray K. (eds) Rhythmic Oscillations in Proteins to Human Cognition. Studies in Rhythm Engineering. Springer, Singapore, 2021; 1, 11-45, doi: 10.1007/978-981-15-7253-1_1.
  13. Cosic I, Cosic D, Lazar K: Analysis of Tumor Necrosis Factor Function Using the Resonant Recognition Model. Cell Biochemistry and Biophysics, 2015; doi: 10.1007/s12013-015-0716-3.
  14. Cosic I, Paspaliaris V, Cosic D: Analysis of Protein-Receptor on an Example of Leptin-Leptin Receptor Interaction Using the Resonant Recognition Model. MDPI Appl. Sci., 2019; 9, 5169, doi:10.3390/app9235169.
  15. Cosic I, Drummond AE, Underwood JR, Hearn MTW: In vitro inhibition of the actions of basic FGF by novel 16 amino acid peptides. Molecular and Cellular Biochemistry, 1994; 130, 1-9.
  16. Krsmanovic V, Biquard JM, Sikorska-Walker M, Cosic I, Desgranges C, Trabaud MA, Whitfield JF, Durkin JP, Achour A, Hearn MT: Investigation Into the Cross-reactivity of Rabbit Antibodies Raised against Nonhomologous Pairs of Synthetic Peptides Derived from HIV-1 gp120 proteins. J.Peptide Res, 1998; 52(5), 410-412.
  17. Hearn MTW, Biquard JM, Cosic I, Krsmanovic V: Peptides Immunologically related to proteins expressed by a viral agent, having a sequence of amino acids ordered by means of protein informational method. US Patent 6 294 174, 2001.
  18. Achour A, Biquard JM, Krsmanovic V, M’Bika JP, Ficheux D, Sikorska M, Cozzone AJ: Induction of Human Immunodeficiency Virus (HIV-1) Envelope Specific Cell-Mediated Immunity by a Non-Homologus Synthetic Peptide. PLoS ONE, 2007; 11, 1-12, doi: 10.1371/journal.pone.0001214.
  19. Almansour N, Pirogova E, Coloe P, Cosic I, Istivan T: Investigation of cytotoxicity of negative control peptides versus bioactive peptides on skin cancer and normal cells: a comparative study. Future Medicinal Chemistry, 2012; 4(12), 1553-1565.
  20. Pirogova E, Istivan T, Gan E, Cosic I: Advances in Methods for Therapeutic Peptide Discovery, Design and Development. Current Pharmaceutical Biotechnology, 2011; 12, 1117-1127.
  21. Istivan T, Pirogova E, Gan E, Almansour N, Coloe P, Cosic I: Biological effects of a De Novo designed myxoma virus peptide analogue: Evaluation of cytotoxicity on tumor cells. Public Library of Science (PLoS) ONE, 2011; 6(9), 1-10.
  22. Cosic I, Kuhar U, Krapez U, Slavec B, Cosic D, Loncarevic I: De Novo Designed Peptide to Prevent SARS-CoV-2 Interaction with ACE2 Receptor on Host Cells. International Journal of Sciences, 2022, 11(2), 1-8, doi: 10.18483/ijSci.2558.
  23. Cosic I, Cosic D: Peptides Inhibiting COVID-19. WO 2022/233856 A1 owned by QuantBioRes A/S. 2022, 10/112022.
  24. Mishra A, Cosic I, Loncarevic I, Cosic D, Fletcher HM: Inhibition of β-lactamase function by de novo designed peptide. PLoS ONE, 2023, 18(9), 1-15, doi: 10.1371/journal.pone.0290845.
  25. Vojisavljevic V, Pirogova E, Cosic I: The Effect of Electromagnetic Radiation (550nm-850nm) on I-Lactate Dehydrogenase Kinetics. Internat J Radiat Biol, 2007; 83, 221-230.
  26. Dotta BT, Murugan NJ, Karbowski LM, Lafrenie RM, Persinger MA: Shifting Wavelength of Ultraweak Photon Emissions from Dying Melanoma Cells: Their Chemical Enhancement and Blocking Are Predicted by Cosic’s Theory of Resonant Recognition Model for Macromolecules. Naturwissenschaften, 2014; 101(2), doi: 10.1007/s00114-013-1133-3.
  27. Murugan NJ, Karbowski LM, Persinger MA: Cosic’s Resonance Recognition Model for Protein Sequences and Photon Emission Differentiates Lethal and Non-Lethal Ebola Strains: Implications for Treatment. Open Journal of Biophysics, 2014; 5, 35.
  28. Karbowski LM, Murugan NJ, Persinger MA: Novel Cosic Resonance (Standing Wave) Solutions for Components of the JAK-STAT Cellular Signalling Pathway: A Convergence of Spectral Density Profiles. FEBS Open Bio, 2015; 5, 245-250.
  29. Cosic I, Paspaliaris V, Cosic D: Explanation of Osteoblastic Differentiation of Stem Cells by Photo Biomodulation Using the Resonant Recognition Model. Appl. Sci., 2019; 9, 1979, doi: 10.3390/app9101979.
  30. Cosic I, Cosic D: The Treatment of Crigler-Najjar Syndrome by Blue Light as Explained by Resonant Recognition Model. EPJ Nonlinear Biomedical Physics, 2016; 4(9), doi: 10.1140/epjnbp/s40366-016-0036-6.
  31. Cosic I, Cosic D, Loncarevic I: New Concept of Small Molecules Interaction with Proteins – An Application to Potential COVID-19 Drugs. International Journal of Sciences, 2020; 9(9), 16-25, doi: 10.18483/ijSci.2390.
  32. Cosic I, Cosic D, Loncarevic I: Analysis of Ivermectin as Potential Inhibitor of SARS-CoV-2 Using Resonant Recognition Model. International Journal of Sciences, 2021; 10(1), 1-6, doi: 10.18483/ijSci.2433.

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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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