The Effects of Aerobic Exercise and Melatonin on Ca Activity in Rats

The Effects of Aerobic Exercise and Melatonin on Ca Activity in Rats



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Volume 4 - May 2015 (05)


The purpose of this study was to determine the effects of Aerobic exercise and Melatonin on carbonic anhydrase activity in rats. In this study, 24 healthy Spraque Dawley male rats, weighing 250–300 g, 4–6 months of age were used. The rats were divided into four equal groups. C; (Control Group), M; (Melatonin Group), E; (Exercise Group), ME, (Melatonin-Exercise Group). The exercise groups (n:12) were run for endurance training at 23oC. The exercise was caried out 6 days a week for 4 weeks.The intensity of endurance training was gradually increased during four weeks. A standard mild electric shock deterrent was used intermittently when necessary to coerce the rats to run. At the end of the fourth week, rats were killed by decapitation on each training day. According to the result of this study, the level of carbonic anhydrase decreases in control, melatonin and “exercise groups and melatonin decreases significantly in exercise group. As a result, it can be said that melatonin and exercise reduces the level of CA in mechanisms related to O2 consumption and CO2 production in organism by having an organizer role.


Melatonin, Carbonic Anhydrase, Aerobic Exercise, Rat


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