Author(s): Fernando Nestor Facio Junior, Luís Cesar Fava Spessoto, Márcio Gatti, Pedro Francisco Ferraz Arruda, José Germano Ferraz Arruda, Thiago Antoniassi, Maria Fernanda Warick Facio
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Volume 4 - Oct 2015
Introduction: Gleason score is a prognostic factor that assists in the determination of treatment for prostate cancer. The aim of the present study was to investigate the prognostic factor of prostate adenocarcinoma related to the Gleason score before (biopsy) and after radical prostatectomy (RP). Methods: A total of 206 patients with localized prostate adenocarcinoma submitted to RP between 2001 and 2008 at a university hospital were analyzed. Results: The predominant total Gleason score was 6 after biopsy and 7 following RP. The 3+3 pattern after biopsy and 3+4 pattern after RP. Biochemical recurrence was found following RP in 34.9% of cases. In 49% of cases, the Gleason score was lower after biopsy than after RP (p < 0.0005). Considering the group with biochemical recurrence, disagreement was found between the Gleason scores after biopsy and post-radical prostatectomy among 68% of the patients and the Gleason score was lower after biopsy than after post-radical prostatectomy in 18.4% (p = 0.62). Conclusions: The correlation between the Gleason score during prostate biopsy and the score of the specimen submitted to anatomopatological analysis following RP was an important prognostic factor of prostate adenocarcinoma before and after RP and should be considered when choosing the treatment approach.
adenocarcinoma, prostatic neoplasms, prognosis, prostatectomy
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