ACP1 - ADA1 Interaction and Human Health

ACP1 - ADA1 Interaction and Human Health

Loading document ...
Loading page ...


Author(s): Gloria-Bottini F, Bottini E

Download Full PDF Read Complete Article

425 847 21-29 Volume 3 - Aug 2014


Background: Biochemical and epidemiological evidence suggest that ACP1 and ADA1 genetic polymorphisms interact with significant phenotypic effects at the clinical level. We have reviewed the observations collected by our group over twenty years on the interaction between these polymorphisms in order to elucidate their impact on human health. Methods: ACP1 and ADA1 phenotypes from 3297 subjects were determined by starch gel electrophoresis on RBC hemolysates. Results: Birth weights are higher in newborns with the ACP1*A/*A and *B/*A genotypes carrying the ADA1*2 than in those with other joint genotypes. During the pre-reproductive and early reproductive stages of extrauterine life, individuals carrying these genotypes are more susceptible to diseases involving the immune system. ACP1*A/*A and *B/*A genotypes carrying the ADA1*2 allele are protected against common diseases occurring during the last stage of life. Conclusions: The joint ACP1-ADA1 system has an important role in human health and development.


ACP1, ADA1, human health, genetic interaction


  1. Gloria-Bottini F, Lucarelli P, Amante A, et al. Interaction at clinical level between erythrocyte acid phosphatase and adenosine deaminase genetic polymorphisms.Hum Genet 1989; 82:213-5
  2. Lucarini N, Borgiani P, Ballarini P, et al. Erythrocyte acid phosphatase (ACP1) activity. In vitro modulation by adenosine and inosine and effects of adenosine deaminase (ADA) polymorphism.Hum Genet 1989; 81:185-7
  3. Bottini N, Gloria-Bottini F, Borgiani P, et al. Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms.Metabolism 2004; 53: 995-1001
  4. Nicotra M, Bottini N, La Torre M, et al.. Repeated spontaneous abortion. Cooperative effects of ADA and ACP1 genetic polymorphisms.Am J Reprod Immunol. (2007); 58:1-10
  5. Ammendola M, Pietropolli A, Saccucci P, et al. Acid phosphatase locus 1 genetic polymorphism, endometriosis, and allergy.Fertil Steril 2008; 90: 1203-5
  6. Saccucci P, Manca Bitti ML, Bottini N, et al. Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms.Med Sci Monit 2009; 15:511-517
  7. Gloria-Bottini F, Saccucci P, Magrini, A et al. Is there a role of ACP1-ADA1 genetic complex in immune reaction? Association with T1D and with past malarial morbidity.Am J Med Sci 2010; 340:268-70
  8. Bottini N, Bottini E, Gloria-Bottini F, et al. Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.Arch Immunol Ther Exp (Warsz) 2002; 50:95-104
  9. Bottini N, Stefanini L, Williams S, et al. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem 2002; 277:24220-4
  10. Chiarugi P, Cirri P, Marra F, et al.. LMW-PTP is a negative regulator of insulin-mediated mitotic and metabolic signalling.Biochem Biophys Res Commun 1997; 238:676-82
  11. Shekels LL, Smith AJ, Van Etten RL, et al. Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase.Protein Sci 1992; 1:710-21
  12. Londos C, Honnor RC, Dhillon GS. cAMP-dependent protein kinase and lipolysis in rat adipocytes. III. Multiple modes of insulin regulation of lipolysis and regulation of insulin responses by adenylate cyclase regulators.J Biol Chem 1985; 260:15139-45
  13. Ohisalo JJ, Strandberg H, Kostiainen E, et al. Stimulation of lipoprotein lipase activity of rat adipose tissue and post-heparin plasma by N6-(phenylisopropyl)adenosine.FEBS Lett 1981; 132:121-3
  14. Vannucci SJ, Nishimura H, Satoh S, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine.Biochem J 1992; 288:325-30
  15. Challis RA, Budohoski L, McManus B, et al. Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker rats. Biochem J 1984; 221: 915-7
  16. Challis RA, Richards SJ, Budohoski L. Characterization of adenosine receptor modulating insulin action in skeletal muscle. Eur. J. Pharmacol 1992;226:121-128
  17. Franco R, Casadó V, Ciruela F, et al. Cell surface adenosine deaminase: much more than an ectoenzyme. Prog Neurobiol 1997; 52: 283-94
  18. Franco R, Aran JM, Colomer D, et al. Association of adenosine deaminase with erythrocyte and platelet plasma membrane: an immunological study using light and electron microscopy.J Histochem Cytochem 1990; 38:653-8
  19. Dong RP, Kameoka J, Hegen M, et al. Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response. J Immunol 1996; 156:1349-55
  20. Ciruela F, Saura C, Canela EI, et al. Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors. FEBS Lett 1996; 380:219-23
  21. Xu B, Berkich DA, Crist GH, et al. A1 adenosine receptor antagonism improves glucose tolerance in Zucker rats.Am J Physiol 1998; 274:271-9
  22. Richardson PJ. Asthma. Blocking adenosine with antisense. Nature 1997; 385:684-5
  23. Yasuda N, Inoue T, Horizoe T, et al. Functional characterization of the adenosine receptor contributing to glycogenolysis and gluconeogenesis in rat hepatocytes.Eur J Pharmacol 2003; 459:159-66
  24. Kameoka J, Tanaka T, Nojima Y, et al. Direct association of adenosine deaminase with a T cell activation antigen, CD26.Science 1993; 261: 466-9
  25. Wurzinger KK, Novotny JE, Mohrenweiser HW. Studies of the purine analog associated modulation of human erythrocyte acid phosphatase activity. Mol Cell Biochem 1985; 66:127-136
  26. Safranow K, Rzeuski R, Binczak-Kuleta A, et al. ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease.Cardiology 2007; 108:275-81
  27. Banci M, Saccucci P, D’Annibale F, et al. ACP1 genetic polymorphism and coronary artery disease: an association study. Cardiology 2009; 113:1236-42
  28. Brackenridge C.. A ternary-associating system of genes. Hum Hered 1997;27:114-117
  29. Engrácia V, Mestriner MA, Cabello PH, et al. Association between the acid phosphatase 1 and adenosine deaminase systems in a Brazilian sample.Hum Hered 1991; 141 :147-50
  30. Hernández JL, Elston RC, Ward LJ. Gametic equilibrium between 24 polymorphic markers.Hum Genet 1990; 85:343-8
  31. Ananthakrisnhan R, Walter H. Some notes on the geographical distribution of the human red cell acid phosphatase phenotypes. Humangenetik 1972;15:177-181
  32. Gloria-Bottini F, Lucarelli P, Lucarini N, et al. Adenosine deaminase-acid phosphatase association and the environment: A study in a continental Italian population.Am J Hum Biol 2000; 12:214-220
  33. Farabegoli A, Barbujani G. Diversity of some gene frequencies in European and Asian populations. VI. Geographic patterns of PGM and ACP.Hum Hered 1990; 40:313-21
  34. Pandey SK, Yu XX, Watts LM, et al. Reduction of low molecular weight5 protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice. J Biol Chem 2007; 282:14291-14299

Cite this Article:

International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

Search Articles

Issue June 2023

Volume 12, June 2023

Table of Contents

World-wide Delivery is FREE

Share this Issue with Friends:

Submit your Paper