ACP1 - ADA1 Interaction and Human Health

ACP1 - ADA1 Interaction and Human Health

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Author(s)

Author(s): Gloria-Bottini F, Bottini E

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413 814 21-29 Volume 3 - Aug 2014

Abstract

Background: Biochemical and epidemiological evidence suggest that ACP1 and ADA1 genetic polymorphisms interact with significant phenotypic effects at the clinical level. We have reviewed the observations collected by our group over twenty years on the interaction between these polymorphisms in order to elucidate their impact on human health. Methods: ACP1 and ADA1 phenotypes from 3297 subjects were determined by starch gel electrophoresis on RBC hemolysates. Results: Birth weights are higher in newborns with the ACP1*A/*A and *B/*A genotypes carrying the ADA1*2 than in those with other joint genotypes. During the pre-reproductive and early reproductive stages of extrauterine life, individuals carrying these genotypes are more susceptible to diseases involving the immune system. ACP1*A/*A and *B/*A genotypes carrying the ADA1*2 allele are protected against common diseases occurring during the last stage of life. Conclusions: The joint ACP1-ADA1 system has an important role in human health and development.

Keywords

ACP1, ADA1, human health, genetic interaction

References

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International Journal of Sciences is Open Access Journal.
This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Author(s) retain the copyrights of this article, though, publication rights are with Alkhaer Publications.

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